Figures & data
Figure 1. Scheme recapitulating the sequence of events leading to the strong non polarized CCL22 production by tumor cells. Healthy epithelial cells secrete low levels of CCL22 in a polarized manner within the luminal acini, their transformation favor their recognition by infiltrating NK cells leading to IFNγ secretion. IFNγ promoted macrophage activation that will produce TNFα and IL-1β after interaction with breast epithelial tumor cells. Combined action of IFNγ, IL-1β and TNFα will induce non polarized strong CCL22 secretion by tumor cells that will induce the recruitment of CCR4+ Treg from periphery, leading to CCR4 internalization.
