Figures & data
Figure 1. Untreated tumors are infiltrated with a high ratio of regulatory T-cells (Treg) to effector T-cells. Dual inhibition of the negative regulatory molecules PD-1 and LAG-3 leads to enhanced CD8:Treg infiltration, proinflammatory cytokine production, and increased survival of tumor-bearing animals.
![Figure 1. Untreated tumors are infiltrated with a high ratio of regulatory T-cells (Treg) to effector T-cells. Dual inhibition of the negative regulatory molecules PD-1 and LAG-3 leads to enhanced CD8:Treg infiltration, proinflammatory cytokine production, and increased survival of tumor-bearing animals.](/cms/asset/e78d2083-7b25-4033-be5d-1cbaf585d693/koni_a_10920593_f0001.gif)