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OncoImmunology Volume 1, 2012 - Issue 7
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Redirecting neutrophils against bladder cancer cells by BCG and Smac mimetic combination

Goodwin Jinesh G. Department of Urology, Unit 1373; The University of Texas MD Anderson Cancer Center; Houston, TX USA
&
Ashish M. Kamat Department of Urology, Unit 1373; The University of Texas MD Anderson Cancer Center; Houston, TX USACorrespondence[email protected]
Pages 1161-1162 | Received 28 May 2012, Accepted 30 May 2012, Published online: 01 Oct 2012

Figures & data

Figure 1. Schematic representation of neutrophil phenotypes and the mechanism of action of BCG-stimulated neutrophils plus Smac mimetics. Although BCG-stimulated neutrophils secrete TNFα, TRAIL and FASL, TNFα appears to be the primary mediator of their anticancer action when combined with Smac mimetics.

Figure 1. Schematic representation of neutrophil phenotypes and the mechanism of action of BCG-stimulated neutrophils plus Smac mimetics. Although BCG-stimulated neutrophils secrete TNFα, TRAIL and FASL, TNFα appears to be the primary mediator of their anticancer action when combined with Smac mimetics.

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