Figures & data
Figure 1. Rage signaling in intestinal tumorigenesis (Fig. 1). In the healthy intestinal epithelium (A), low levels of damage-associated molecular patterns (DAMPs) fail to activate Rage. In intestinal adenomas (B), high levels of DAMPs derive from damaged or dying cells. These DAMPS activate Rage, which increases the production of DAMPs such as HMGB1 and S100, which in turn sustain an inflammatory and pro-tumorigenic milieu. In the absence of Rage (C), DAMPs fail to initiate an inflammatory response, resulting in limited tumorigenesis.
