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Is preexisting antitumor CD4 T cell response indispensable for the chemotherapy induced immune regression of cancer?

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Pages 1617-1619 | Published online: 06 Dec 2012

Figures & data

Figure 1. Role of preexisting antitumor CD4+ T-cell responses in the chemotherapy-induced immune regression of cancer. (1) Effective chemotherapy induces immunological tumor cell death and tumor antigen release. (2) Tumor antigens are uptaked and processed by dendritic cells. (3) Activation of preexisting tumor-specific CD4 Th1 cells promote an antitumor immunity that acts in synergy with chemotherapy effect.

Figure 1. Role of preexisting antitumor CD4+ T-cell responses in the chemotherapy-induced immune regression of cancer. (1) Effective chemotherapy induces immunological tumor cell death and tumor antigen release. (2) Tumor antigens are uptaked and processed by dendritic cells. (3) Activation of preexisting tumor-specific CD4 Th1 cells promote an antitumor immunity that acts in synergy with chemotherapy effect.