OncoImmunology, Volume 1, Issue 9 (2012)

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OncoImmunology, Volume 1, Issue 9 (2012)

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Editorial

Editorial
Advancing the field of cancer immunotherapy
MIATA consensus guidelines become available to improve data reporting and interpretation for T-cell immune monitoring
Axel Hoos, Sylvia Janetzki & Cedrik M. Britten
Pages: 1457-1459
Published online: 06 Dec 2012
First Page PreviewforAdvancing the field of cancer immunotherapy | Full Text | References | PDF (148.8 KB)
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Original Research

Article
IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan
Richard Metz, Sonja Rust, James B. DuHadaway, Mario R. Mautino, David H. Munn, Nicholas N. Vahanian, Charles J. Link & George C. Prendergast
Pages: 1460-1468
Published online: 06 Dec 2012
AbstractforIDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan | PDF (922.7 KB) | Supplemental
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Research Paper

Article
Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin’s lymphoma
Jason Kato, Robert T. O’Donnell, Mastewal Abuhay & Joseph M. Tuscano
Pages: 1469-1475
Published online: 06 Dec 2012
AbstractforEfficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin’s lymphoma | Full Text | References | PDF (744 KB)
  • 860 Views
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Article
BRAF inhibition improves tumor recognition by the immune system
Potential implications for combinatorial therapies against melanoma involving adoptive T-cell transfer
Marco Donia, Paolo Fagone, Ferdinando Nicoletti, Rikke Sick Andersen, Estrid Høgdall, Per thor Straten, Mads Hald Andersen & Inge Marie Svane
Pages: 1476-1483
Published online: 06 Dec 2012
AbstractforBRAF inhibition improves tumor recognition by the immune system | Full Text | References | PDF (620.3 KB) | Supplemental
  • 1104 Views
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Article
Myeloid-derived suppressor cells expand during breast cancer progression and promote tumor-induced bone destruction
Sabrina Danilin, Alyssa R. Merkel, Joshua R. Johnson, Rachelle W. Johnson, James R. Edwards & Julie A. Sterling
Pages: 1484-1494
Published online: 06 Dec 2012
AbstractforMyeloid-derived suppressor cells expand during breast cancer progression and promote tumor-induced bone destruction | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1722 Views
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Article
A TLR4-interacting peptide inhibits lipopolysaccharide-stimulated inflammatory responses, migration and invasion of colon cancer SW480 cells
Madhusoodhanan Rakhesh, Moriasi Cate, Ramani Vijay, Anant Shrikant & Awasthi Shanjana
Pages: 1495-1506
Published online: 06 Dec 2012
AbstractforA TLR4-interacting peptide inhibits lipopolysaccharide-stimulated inflammatory responses, migration and invasion of colon cancer SW480 cells | Full Text | References | PDF (1.8 MB)
  • 1288 Views
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Open Access
Article
Inefficient boosting of antitumor CD8+ T cells by dendritic-cell vaccines is rescued by restricting T-cell cytotoxic functions
Joel Zhi-Iong Ma, Jianping Yang, Jim S. Qin, Antonia Richter, Rachel Perret, Wafik S. El-Deiry, Niklas Finnberg & franca ronchese
Pages: 1507-1516
Published online: 06 Dec 2012
AbstractforInefficient boosting of antitumor CD8+ T cells by dendritic-cell vaccines is rescued by restricting T-cell cytotoxic functions | Full Text | References | PDF (1,021.4 KB)
  • 686 Views
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Article
Macrophages mediate colon carcinoma cell adhesion in the rat liver after exposure to lipopolysaccharide
Nuray Gül, Simran Grewal, Marijn Bögels, Gerben J. van der Bij, Malika M.A. Koppes, Steven J. Oosterling, Donna M. Fluitsma, Kees A. Hoeben, Robert H. J. Beelen & Marjolein van Egmond
Pages: 1517-1526
Published online: 06 Dec 2012
AbstractforMacrophages mediate colon carcinoma cell adhesion in the rat liver after exposure to lipopolysaccharide | Full Text | References | PDF (2.8 MB) | Supplemental
  • 621 Views
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Article
Cardiotrophin-1 determines liver engraftment of syngenic colon carcinoma cells through an immune system-mediated mechanism
Matilde Bustos, Juan Dubrot, Eduardo Martinez-Anso, Eduardo Larequi, David Castaño, Asis Palazon, Idoia Belza, Miguel F. Sanmamed, Jose Luis Perez-Gracia, Carlos Ortiz de Solorzano, Carlos alfaro & Ignacio Melero
Pages: 1527-1536
Published online: 06 Dec 2012
AbstractforCardiotrophin-1 determines liver engraftment of syngenic colon carcinoma cells through an immune system-mediated mechanism | Full Text | References | PDF (1.1 MB) | Supplemental
  • 909 Views
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Article
HER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model
Gene gun is superior to jet injector in inducing CTL responses and protective immunity
Tam Nguyen-Hoai, Dennis Kobelt, Oliver Hohn, Minh D. Vu, Peter M. Schlag, Bernd Dörken, Steven Norley, Martin Lipp, Wolfgang Walther, Antonio Pezzutto & Jörg Westermann
Pages: 1537-1545
Published online: 06 Dec 2012
AbstractforHER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model | Full Text | References | PDF (500.5 KB)
  • 780 Views
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Article
Immunization with a prostate cancer xenoantigen elicits a xenoantigen epitope-specific T-cell response
Laura E. Johnson, Thomas P. Frye & Douglas G. McNeel
Pages: 1546-1556
Published online: 06 Dec 2012
AbstractforImmunization with a prostate cancer xenoantigen elicits a xenoantigen epitope-specific T-cell response | Full Text | References | PDF (457.3 KB)
  • 573 Views
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Review

Review Article
Trial watch
Peptide vaccines in cancer therapy
Erika Vacchelli, Isabelle Martins, Alexander Eggermont, Wolf Hervé Fridman, Jerome Galon, Catherine Sautès-Fridman, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi
Pages: 1557-1576
Published online: 06 Dec 2012
AbstractforTrial watch | Full Text | References | PDF (315.4 KB)
  • 1297 Views
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Review Article
How do CARs work?
Early insights from recent clinical studies targeting CD19
Marco L. Davila, Renier Brentjens, Xiuyan Wang, Isabelle Rivière & Michel Sadelain
Pages: 1577-1583
Published online: 06 Dec 2012
AbstractforHow do CARs work? | Full Text | References | PDF (543.2 KB)
  • 3303 Views
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Review Article
Melanoma-infiltrating dendritic cells
Limitations and opportunities of mouse models
Jared S. Klarquist & Edith M. Janssen
Pages: 1584-1593
Published online: 06 Dec 2012
AbstractforMelanoma-infiltrating dendritic cells | Full Text | References | PDF (698.2 KB)
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Point of View

Senescence and NFκB
A trojan horse in tumors?
Elvira Crescenzi, Raffaele De Palma & Antonio Leonardi
Pages: 1594-1597
Published online: 06 Dec 2012
AbstractforSenescence and NFκB | Full Text | References | PDF (231 KB)
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Author's View

Killing from within
John B. Mumm, Jan Emmerich & Martin Oft
Pages: 1598-1600
Published online: 06 Dec 2012
AbstractforKilling from within | Full Text | References | PDF (441.8 KB)
  • 495 Views
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Surviving host innate immunity
Cancer cells can turn a deadly assault into an advantage
Pnina Brodt
Pages: 1601-1603
Published online: 06 Dec 2012
AbstractforSurviving host innate immunity | Full Text | References | PDF (405.6 KB)
  • 379 Views
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Open Access
Modulating CD27 signaling to treat cancer
Carsten Riether, Christian Schürch & Adrian F. Ochsenbein
Pages: 1604-1606
Published online: 06 Dec 2012
AbstractforModulating CD27 signaling to treat cancer | Full Text | References | PDF (406.2 KB)
  • 943 Views
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Melanoma immunoediting by NK cells
Mirna Balsamo, Gabriella Pietra, William Vermi, Lorenzo Moretta, Maria Cristina Mingari & Massimo Vitale
Pages: 1607-1609
Published online: 06 Dec 2012
AbstractforMelanoma immunoediting by NK cells | Full Text | References | PDF (313.9 KB)
  • 635 Views
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Radiotherapy supports protective tumor-specific immunity
Anurag Gupta, Anu Sharma, Lotta von Boehmer, Laura Surace, Alexander Knuth & Maries van den Broek
Pages: 1610-1611
Published online: 06 Dec 2012
AbstractforRadiotherapy supports protective tumor-specific immunity | Full Text | References | PDF (225.4 KB)
  • 610 Views
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Next-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors
Giuliana Amaddeo, Cécile Guichard, Sandrine Imbeaud & Jessica Zucman-Rossi
Pages: 1612-1613
Published online: 06 Dec 2012
AbstractforNext-generation sequencing identified new oncogenes and tumor suppressor genes in human hepatic tumors | Full Text | References | PDF (306.4 KB)
  • 789 Views
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Immunotherapy of acute myeloid leukemia based on γδ T cells
Julie Gertner-Dardenne, Cyril Fauriat, Norbert Vey & Daniel Olive
Pages: 1614-1616
Published online: 06 Dec 2012
AbstractforImmunotherapy of acute myeloid leukemia based on γδ T cells | Full Text | References | PDF (301.6 KB)
  • 688 Views
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Is preexisting antitumor CD4 T cell response indispensable for the chemotherapy induced immune regression of cancer?
Yann Godet, Magalie Dosset, Christophe Borg & Olivier Adotevi
Pages: 1617-1619
Published online: 06 Dec 2012
AbstractforIs preexisting antitumor CD4 T cell response indispensable for the chemotherapy induced immune regression of cancer? | Full Text | References | PDF (370 KB)
  • 495 Views
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Antigen shedding into the circulation contributes to tumor immune escape
Bastian Höchst & Linda Diehl
Pages: 1620-1622
Published online: 06 Dec 2012
AbstractforAntigen shedding into the circulation contributes to tumor immune escape | Full Text | References | PDF (296.4 KB)
  • 911 Views
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Tumor-infiltrating B cells and T cells
Working together to promote patient survival
Julie S. Nielsen & Brad H. Nelson
Pages: 1623-1625
Published online: 06 Dec 2012
AbstractforTumor-infiltrating B cells and T cells | Full Text | References | PDF (263.5 KB)
  • 1323 Views
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Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide
Mariana Malvicini, Flavia Piccioni, Juan Bayo, Esteban Fiore, Catalina Atorrasagasti, Laura Alaniz, Mariana Garcia, Jorge B. Aquino, Manuel Gidekel, Pablo Matar & Guillermo Mazzolini
Pages: 1626-1628
Published online: 06 Dec 2012
AbstractforChemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide | PDF (372.6 KB)
  • 136 Views
  • 3 CrossRef citations
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Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
Inge Verbrugge, Mara Galli, Mark J. Smyth, Ricky W. Johnstone & Nicole M. Haynes
Pages: 1629-1631
Published online: 06 Dec 2012
AbstractforEnhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies | PDF (1.1 MB)
  • 242 Views
  • 9 CrossRef citations
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Regulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment
Masahisa Jinushi
Pages: 1632-1634
Published online: 06 Dec 2012
AbstractforRegulatory mechanisms of nucleic acid-mediated innate immune responses in the tumor microenvironment | PDF (407.6 KB)
  • 204 Views
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In vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation
Guido Ferlazzo
Pages: 1635-1636
Published online: 06 Dec 2012
AbstractforIn vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation | PDF (294.4 KB)
  • 146 Views
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Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8+ T cells
Jan Emmerich, John B. Mumm & Martin Oft
Pages: 1637-1639
Published online: 06 Dec 2012
AbstractforAutochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8+ T cells | PDF (286.8 KB)
  • 215 Views
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Open Access
Anticancer activity of cardiac glycosides
At the frontier between cell-autonomous and immunological effects
Oliver Kepp, Laurie Menger, Erika Vacchelli, Sandy Adjemian, Isabelle Martins, Yuting Ma, Abdul Qader Sukkurwala, Mickaël Michaud, Lorenzo Galluzzi, Laurence Zitvogel & Guido Kroemer
Pages: 1640-1642
Published online: 06 Dec 2012
AbstractforAnticancer activity of cardiac glycosides | Full Text | References | PDF (310.6 KB)
  • 1570 Views
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High-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them
Susanne Wilde & Dolores J. Schendel
Pages: 1643-1644
Published online: 06 Dec 2012
AbstractforHigh-quality and high-avidity T cell clones specific for tumor-associated antigens and how to find them | Full Text | References | PDF (153.2 KB)
  • 542 Views
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Radiation and immunotherapy
Renewed allies in the war on cancer
Steven K. Seung, Brendan Curti, Marka Crittenden & Walter Urba
Pages: 1645-1647
Published online: 06 Dec 2012
AbstractforRadiation and immunotherapy | Full Text | References | PDF (437.9 KB)
  • 614 Views
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Emerging evidence of anti-tumor immune control in the central nervous system
Andrew M. Donson & Nicholas K. Foreman
Pages: 1648-1649
Published online: 06 Dec 2012
AbstractforEmerging evidence of anti-tumor immune control in the central nervous system | Full Text | References | PDF (189.7 KB)
  • 346 Views
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Targeting MDSCs enhance therapeutic vaccination responses against lung cancer
Minu K. Srivastava, Steven Dubinett & Sherven Sharma
Pages: 1650-1651
Published online: 06 Dec 2012
AbstractforTargeting MDSCs enhance therapeutic vaccination responses against lung cancer | Full Text | References | PDF (161.3 KB)
  • 577 Views
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Licensing of γδT cells for professional antigen presentation
A new role for antibodies in regulation of antitumor immune responses
John Anderson, Kenth Gustafsson, Nourredine Himoudi, Mengyong Yan & Jennifer Heuijerjans
Pages: 1652-1654
Published online: 06 Dec 2012
AbstractforLicensing of γδT cells for professional antigen presentation | Full Text | References | PDF (248.8 KB)
  • 637 Views
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Enhancing anti-melanoma immunity by electrochemotherapy and in vivo dendritic-cell activation
Gianni Gerlini, Paola Di Gennaro & Lorenzo Borgognoni
Pages: 1655-1657
Published online: 06 Dec 2012
AbstractforEnhancing anti-melanoma immunity by electrochemotherapy and in vivo dendritic-cell activation | Full Text | References | PDF (447.8 KB)
  • 546 Views
  • 32 CrossRef citations
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Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma
Ross Brown, Hayley Suen, James Favaloro, Shihong Yang, P. Joy Ho, John Gibson & Douglas Joshua
Pages: 1658-1660
Published online: 06 Dec 2012
AbstractforTrogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma | Full Text | References | PDF (333.7 KB)
  • 702 Views
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How imiquimod licenses plasmacytoid dendritic cells to kill tumors
Martin Holcmann, Barbara Drobits & Maria Sibilia
Pages: 1661-1663
Published online: 06 Dec 2012
AbstractforHow imiquimod licenses plasmacytoid dendritic cells to kill tumors | Full Text | References | PDF (417.3 KB)
  • 827 Views
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