Getting by with a little help from the right CD4⁺ T cells

Figures & data

Figure 1. Synergic effects of tumor-associated antigen-specific CD4⁺ T_H cells and CD8⁺ T cells against brain cancer. (A) In vitro polarized T_H1 cells preferentially infiltrate an intracranial tumor. (B) T_H1 cells specific for a tumor-associated antigen enhanced the infiltration of neoplastic lesions by CD8⁺ T cells and the ability of the latter to secrete cytokines. (C) Both T_H1 and T_H2 T cells have therapeutic effects when co-administered with CD8⁺ T cells, potentially owing to in vivo repolarization. APC, antigen-presenting cell; IFNγ, interferon γ; IL, interleukin.