Advanced search
Publication Cover
OncoImmunology Volume 2, 2013 - Issue 9
Submit an article Journal homepage
715
Views
31
CrossRef citations to date
0
Altmetric
Author's View

Combining conventional chemotherapy and γδ T cell-based immunotherapy to target cancer-initiating cells

Matilde Todaro Biomedical Research Centre; University of Palermo; Palermo, Italy; Department of Surgical and Anatomical Disciplines; University of Palermo; Palermo, Italy
,
Serena Meraviglia Department of Biopathology and Biotechnology; University of Palermo; Palermo, Italy
,
Nadia Caccamo Biomedical Research Centre; University of Palermo; Palermo, Italy; Department of Biopathology and Biotechnology; University of Palermo; Palermo, Italy
,
Giorgio Stassi Department of Surgical and Anatomical Disciplines; University of Palermo; Palermo, Italy
&
Francesco Dieli Biomedical Research Centre; University of Palermo; Palermo, Italy; Department of Biopathology and Biotechnology; University of Palermo; Palermo, ItalyCorrespondence[email protected]
Article: e25821 | Received 19 Jul 2013, Accepted 20 Jul 2013, Published online: 29 Jul 2013

Figures & data

Figure 1. Combinatorial antineoplastic effects of conventional chemotherapy and γδ T cell-based immunotherapy. Commonly used chemotherapeutic agents such as 5-fluorouracil (5-FU) and doxorubicin (DXR) stimulate colon cancer-initiating cells to express increased amounts of death receptor 5 (CR5), rendering them susceptible to the TNF-related apoptosis inducing ligand (TRAIL) dependent cytotoxic activity of Vγ9Vδ2 T cells, following the natural killer group 2 member D (NKG2D)-dependent recognition of stress-induced ligands. MIC, MHC class I polypeptide-related sequence; ULBP, UL16-binding protein.

Figure 1. Combinatorial antineoplastic effects of conventional chemotherapy and γδ T cell-based immunotherapy. Commonly used chemotherapeutic agents such as 5-fluorouracil (5-FU) and doxorubicin (DXR) stimulate colon cancer-initiating cells to express increased amounts of death receptor 5 (CR5), rendering them susceptible to the TNF-related apoptosis inducing ligand (TRAIL) dependent cytotoxic activity of Vγ9Vδ2 T cells, following the natural killer group 2 member D (NKG2D)-dependent recognition of stress-induced ligands. MIC, MHC class I polypeptide-related sequence; ULBP, UL16-binding protein.

Related Research Data

Cancer Stem Cells Targeting; the Lessons from the Interaction of the Immune System, the Cancer Stem Cells and the Tumor Niche
Source: Taylor & Francis
Tuning cancer fate: the unremitting role of host immunity.
Source: The Royal Society
γδ cell-based immunotherapy for cancer.
Source: Informa UK Limited
γδ T Cells and Tumor Microenvironment: From Immunosurveillance to Tumor Evasion.
Source: Frontiers Media SA
In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells.
Source: MDPI AG
Current Advances in γδ T Cell-Based Tumor Immunotherapy.
Source: Frontiers Media S.A.

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.