Figures & data
Figure 1. Pro-tumorigenic role of REG3β in pancreatic adenocarcinoma. Regenerating islet-derived 3β (REG3β) secreted by the acinar cells that surround pancreatic tumors acts in a paracrine manner on peri-tumoral macrophages, hence skewing them toward the M2 phenotype. REG3β operates by activating signal transducer and activator of transcription 3 (STAT3), a transcription factor that is required for the development and progression of pancreatic cancer.
![Figure 1. Pro-tumorigenic role of REG3β in pancreatic adenocarcinoma. Regenerating islet-derived 3β (REG3β) secreted by the acinar cells that surround pancreatic tumors acts in a paracrine manner on peri-tumoral macrophages, hence skewing them toward the M2 phenotype. REG3β operates by activating signal transducer and activator of transcription 3 (STAT3), a transcription factor that is required for the development and progression of pancreatic cancer.](/cms/asset/1d3f9510-bb2a-4ccb-b5c7-2999caeb7165/koni_a_10926404_f0001.gif)