Figures & data
Figure 1. Targeting the epithelial-to-mesenchymal transition to block metastatic dissemination and alleviate resistance to therapy. (A) The epithelial-to-mesenchymal transition (EMT) promotes the invasive potential of cancer cells, their propensity to generate distant metastases and their resistance to chemo- and radiotherapy. (B) A vaccine directed against a driver of EMT could elicit an immune response that effectively targets malignant cells undergoing the EMT. Combining this immunotherapeutic approach with conventional treatments targeting epithelial cancer cells might result in effective tumor eradication.
