Genetic variants of IgG1 antibodies and FcγRIIIa receptors influence the magnitude of antibody-dependent cell-mediated cytotoxicity against prostate cancer cells

Figures & data

Table 1. Inhibition of HuHMFG1-dependent NK cell-mediated ADCC by different FCGR3A genotypes in the presence of allotypically disparate IgG1 antibodies

IgG1 allotype	FCGR3A variants	Inhibition of ADCC	P value
GM 3+, 1-, 2-	VV	92.87 ± 8.61%	0.00000046
	FF	50.41 ± 2.94%
GM 17+, 1+, 2+	VV	31.04 ± 20.65%	0.15
	FF	48.56 ± 18.24%
GM 17+,1+, 2-	VV	87.70 ± 6.72%	0.00018
	FF	43.86 ± 17.32%

Abbreviations: ADCC, antibody-dependent cell-mediated cytotoxicity; FCGR3A, Fc fragment of IgG, low affinity IIIa receptor (CD16a); NK, natural killer.