Figures & data
Figure 1. Role of integrin αvβ3 in lung colonization by cancer cells. Activated integrin αvβ3 on renal cell carcinoma (RCC) and soft tissue sarcoma (STS) cells facilitates their binding to blood clots. This in turn sustains the formation of invadopodia along with the assembly of an elaborate fibronectin (FN) matrix, the formation of actin stress fibers and upregulation of snail family zinc finger 2 (SNAI2), best known as SLUG. Altogether, these factors contribute to the metastatic colonization of the lung by malignant cells.
