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Chemotherapeutic targeting of myeloid-derived suppressor cells

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Article: e27359 | Received 25 Nov 2013, Accepted 27 Nov 2013, Published online: 01 Jan 2014

Figures & data

Figure 1. The multifaceted effects of doxorubicin on antitumor immunity. As it depletes myeloid-derived suppressor cells (MDSCs), promotes the immunogenic demise of cancer cells, and improves the activity of effector lymphocytes, doxorubicin may be efficiently combined with the adoptive transfer of helper T cells.

Figure 1. The multifaceted effects of doxorubicin on antitumor immunity. As it depletes myeloid-derived suppressor cells (MDSCs), promotes the immunogenic demise of cancer cells, and improves the activity of effector lymphocytes, doxorubicin may be efficiently combined with the adoptive transfer of helper T cells.