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Iron-induced parafibrin formation in tumors fosters immune evasion

Article: e28539 | Received 17 Feb 2014, Accepted 14 Mar 2014, Published online: 25 Apr 2014

Figures & data

Figure 1. Conceptual scenarios of the interaction between natural killer cells and cancer cells. Natural killer (NK) cells attack those tumor cells that appear to as “non-self,” but spare the “self” identified cancer cells, including those coated with “self” parafibrin polypetide chains.

Figure 1. Conceptual scenarios of the interaction between natural killer cells and cancer cells. Natural killer (NK) cells attack those tumor cells that appear to as “non-self,” but spare the “self” identified cancer cells, including those coated with “self” parafibrin polypetide chains.

Figure 2. Displacement of parafibrin protective coat from the cancer cell membrane by an amphiphilic substance. The hydrophobic groups of the amphiphilate form strong complexes with those of cancer cell membrane, thus diplacing the polypeptide backbone of parafibrin thereby increasing its water solubility due to hydrophilic group enrichment.

Figure 2. Displacement of parafibrin protective coat from the cancer cell membrane by an amphiphilic substance. The hydrophobic groups of the amphiphilate form strong complexes with those of cancer cell membrane, thus diplacing the polypeptide backbone of parafibrin thereby increasing its water solubility due to hydrophilic group enrichment.

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