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Tertiary lymphoid structures in human lung cancers, a new driver of antitumor immune responses

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Article: e28976 | Received 14 Apr 2014, Accepted 23 Apr 2014, Published online: 29 May 2014

Figures & data

Figure 1. Cancer-associated tertiary lymphoid structures drive antitumor immune responses. In the lung tumor microenvironment, the presence of tertiary lymphoid structures (TLS) may foster the immigration of immune cells via high endothelial venules (HEVs), thereby promoting a protective cellular immune response that ultimately positively affects the clinical outcome of cancer patients.

Figure 1. Cancer-associated tertiary lymphoid structures drive antitumor immune responses. In the lung tumor microenvironment, the presence of tertiary lymphoid structures (TLS) may foster the immigration of immune cells via high endothelial venules (HEVs), thereby promoting a protective cellular immune response that ultimately positively affects the clinical outcome of cancer patients.

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