Figure 1. Immunosurveillance stimulated by GR9-B11 fibrosarcoma cells restrains spontaneous metastases in permanent dormancy. Cytotoxic T lymphocytes (CTLs) are directly implicated in this phenomenon. Depletion of T lymphocytes or asialo-GM1+ cells via antibody-based immunodepletion promotes the “awakening” of overt pulmonary metastases from disseminated metastatic cells.
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