Figure 1. The effect of the pan-Bcl-2 inhibitor GX15 on subsets of human T cells. (A) T-cell subsets in peripheral blood showed differential sensitivity to GX15 based on their activation, memory, and proliferative status. (B) GX15 preferentially reduced the proportion of Tregs in peripheral blood and altered their phenotype and function, potentially tipping the balance of immune cells toward effector memory T cells in the human tumor microenvironment.
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