Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

Figures & data

Figure 1 Schematic model for the cooperative interactions of PTEN deficiency and RAS activation. (A) Activated RAS (RAS*) causes RAF/MAPK activation and PI3K/AKT activation, increasing pAKT1 and 3 preferentially. (B) PTEN inactivation and RAS activation cooperates to increase pAKT2 along with pAKT1 and pAKT3.

Table 1 Top 5 genes mutated in malignant melanoma

Gene name	Sample number	Positive samples	Percent mutated
BRAF	5492	2269	41%
NRAS	3461	686	20%
CDKN2A	1056	281	27%
KIT	1098	89	8%
PTEN	544	85	16%

The mutation data was obtained from the Sanger Institute Catalogue Of Somatic Mutations In Cancer Web site, (http://www.sanger.ac.uk/cosmic).30

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