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Genomic occupancy of the transcriptional co-activators p300 and CBP

Per-Henrik Holmqvist The Wenner-Gren Institute; Developmental Biology; Stockholm University; Arrheniuslaboratories E3, SE-106 91 Stockholm, Sweden
&
Mattias Mannervik The Wenner-Gren Institute; Developmental Biology; Stockholm University; Arrheniuslaboratories E3, SE-106 91 Stockholm, SwedenCorrespondence[email protected]
Pages 18-23 | Received 02 Oct 2012, Accepted 19 Oct 2012, Published online: 06 Nov 2012

Figures & data

Figure 1. (A) Genes that are silenced by Polycomb-mediated H3K27me3 (K27me) can be occupied by p300/CBP. Association of p300/CBP with silent or poised transcriptional enhancers (with or without H3K27me3) does not result in histone acetylation. (B) At active genes, p300/CBP can acetylate histones on H3K27 (K27ac) and H3K18 (not shown), acetylate transcription factors (Ac), function as a scaffolds for recruiting other proteins, or help establish a preinitiation complex by interactions with TFIIB and hypophosphorylated RNA polymerase II.

Figure 1. (A) Genes that are silenced by Polycomb-mediated H3K27me3 (K27me) can be occupied by p300/CBP. Association of p300/CBP with silent or poised transcriptional enhancers (with or without H3K27me3) does not result in histone acetylation. (B) At active genes, p300/CBP can acetylate histones on H3K27 (K27ac) and H3K18 (not shown), acetylate transcription factors (Ac), function as a scaffolds for recruiting other proteins, or help establish a preinitiation complex by interactions with TFIIB and hypophosphorylated RNA polymerase II.

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