Figures & data
Figure 1 Model of the signaling cascade in response to the release of dsRNA from LRV particles, production of IFNβ and secretion of proinflammatory cytokines and chemokines. The main pathway involved in this process is highlighted in bold. (1) Phagocytosis of LRV infected promastigotes by phagocytes (macrophages); (2) promastigotes differentiate into amatigotes, which reside in phagolysosomes; (3) death of some parasites (promastigotes and amastigotes), release of LRV and of dsRNA, which binds to TLR3; (4) activation of TLR3 via TRIF and signal transmission via the transcription factors IRF3 and NFκB; (5) activation and secretion of IFNβ; (6) binding of IFNβ to its receptor and activation of pro-inflammatory cytokines and chemokines genes (autocrine loop); (7) synthesis and secretion of pro-inflammatory cytokines and chemokines such as TNFα, IL-6, CCL and CXCL10 leading to increased parasitemia and pathology.
