Strength in numbers

Figures & data

Table 1. Genome-wide studies on the host response in C. elegans

Pathogen	Method (proteomics/ transcriptomics)	Time of sampling	References
B. thuringiensis	T	8 h	Boehnisch et al.^18
S. aureus	P	1, 4, 8, 24 h	Bogaerts et al.^21
A. hydrophila	P	1, 3, 5 d	Bogaerets et al.^22
Y. pestis	T	24 h	Bolz et al.^17
S. marcescens, E. faecalis, P. luminescens, D. coniospora and Harposporium sp	T	24 h (D. coniospora 12 h)	Engelmann et al.^7
B. thuringiensis toxin Cry5B	T	3 h	Huffman et al.^20
S. aureus	T	8 h	Irazoqui et al.^10
M. nematophilum	T	6 h	O'Rourke et al.^14
D. coniospora	T	24 h	Pujol et al.^13
C. albicans	T	4 h	Pukkila-Worley et al.^8
P. aeruginosa	T	4, 12, 24 h	Shapira et al.^15
E. coli LF82	P	24, 72 h	Simonsen et al.^23
P. aeruginosa	T	4, 8 h	Troemel et al.^16
S. marcescens, P. luminescens, E. faecalis and E. carotovora	T	24 h	Wong et al.^19

Figure 1. The core C. elegans immune response is enriched in several protein families and domains. Pie chart of the protein classes enriched in the core immune host response defined as genes/proteins being regulated in eight or more genome-wide experiments of the C. elegans response to different pathogens. The full list of genome-wide experiments can be seen in Table 1 and a list of the core response genes/proteins is found Table S1. The enrichment analysis was performed using DAVID v. 6.7 (http://david.abcc.ncifcrf.gov/).⁷¹

Figure 2. Hierarchical clustering analysis of the core immune response in C. elegans. The clustering analysis was performed using the software MeV v4.8. Green indicates induction of the corresponding gene/protein and red indicates repression under the designated condition.

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