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Editorial

“If you bring an alarm, we will destroy it,” said Brucella to the host cell

Pages 460-462 | Received 01 May 2014, Accepted 01 May 2014, Published online: 01 May 2014

Figures & data

Figure 1. A schematic view of Brucella entry into a cell. Brucella uses different effector proteins that help the bacterium to travel from endosomes to finally hide inside the endoplasmic reticulum. We hypothesize that InvA protein acts at the level of entry during the first step of Brucella intracellular trafficking, followed by the action of the cyclic glucan (CbG), then RicA between late endosomes and the endoplasmic reticulum, and finally in the endoplasmic reticulum with BtpA and BtpB controlling host cell signaling.

Figure 1. A schematic view of Brucella entry into a cell. Brucella uses different effector proteins that help the bacterium to travel from endosomes to finally hide inside the endoplasmic reticulum. We hypothesize that InvA protein acts at the level of entry during the first step of Brucella intracellular trafficking, followed by the action of the cyclic glucan (CbG), then RicA between late endosomes and the endoplasmic reticulum, and finally in the endoplasmic reticulum with BtpA and BtpB controlling host cell signaling.