MAGNETIC STIMULATION OF THE BRAIN INCREASE Na⁺, K⁺-ATPase ACTIVITY DECREASED BY INJECTION OF AlCl₃ INTO NUCLEUS BASALIS MAGNOCELLULARIS OF RATS

Abstract

This article reports here on the influence of the static magnetic fields (MFs), locally applied to the brain area, on Na, K-ATPase activity in the rat with lesioned nucleus basalis magnocellularis (NBM) by intracerebral injection of 5 μl, 1% AlCl₃ into the nucleus. Two AKMA micromagnets (M) flux density of 60 miliTesla, 5 mm in diameter, were bilaterally implanted with “N” polarity facing down to the cranial bones in the vicinity of the pineal gland (PG), immediately after the lesioning of NBM, during the same operation procedure. Ten days after the lesions of NBM, Na, K-ATPase activity on the erythrocyte membranes in the peripheral blood, measured spectrophotometrically, was completely inhibited. Magnetic stimulation (60 mT) of the brain during the 10 days significantly increased Na, K-ATPase activity on the erythrocyte membranes of rats with lesioned NBM. This results suggests that altered by lesions Na, K-ATPase activity in an experimental model of Alzheimer's disease might be ameliorated by magnetic stimulation of the brain.

Keywords:

• AlCl₃
• erythrocyte membranes
• Na
• K-ATPase
• rat
• nucleus basalis magnocellularis
• stationary magnetic fields