203
Views
8
CrossRef citations to date
0
Altmetric
Original Articles

Fabrication and Properties of Gelatin/Chitosan Microspheres Loaded with 5-Fluorouracil

, , , , , , , & show all
Pages 973-983 | Received 22 May 2012, Accepted 30 Oct 2012, Published online: 04 Apr 2013
 

Abstract

The use of microspheres as drug delivery vehicles for anticancer therapeutics has great potential to revolutionize the future of cancer therapy. The present paper describes the influence of process variables on the encapsulation and loading efficiency of 5-Fluorouracil (5-FU) in gelatin/chitosan (Gel/Cs) microspheres. The influences of preparation parameters, including the contents of the emulsifier Span-80, the cross-linking agent and 5-FU, and the stirring speed, on drug loading and encapsulation efficiency of the microspheres were investigated. The experimental results indicated that drug loading and encapsulation efficiency of microspheres increased with increasing concentration of the cross-linking agent; and then decreased when the concentration of the cross-linking agent was higher than 0.3 ml·g−1 of Gel/Cs. Drug loading and encapsulation efficiency increased with increasing concentration of Span-80; they reached the maximum value when the concentration of the emulsifier was 0.012 g·ml−1. The loading and encapsulation efficiency of the microspheres also increased with increasing stirring speed. In addition, drug loading and encapsulation efficiency increased with increasing concentration of 5-FU; however, the encapsulation efficiency decreased when the concentration of 5-FU was higher than 40 mg·ml−1.

Acknowledgments

This work was financially supported by the National Natural Science Fund of China (No. 51273062), Hunan Provincial Natural Science Foundation of China (No. 12JJA003), the Scientific Research Fund of Hunan Provincial Education Department (No. 11B045) and the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,107.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.