67
Views
0
CrossRef citations to date
0
Altmetric
Articles

Synthesis and Characterization of Gelatin/Poly N-Isopropylacryl Amide Nanocomposite Hydrogels by Response Surface Methodology

, &
Pages 329-349 | Received 23 Jan 2023, Accepted 03 May 2023, Published online: 30 May 2023
 

Abstract

In this study, after producing Poly N-isopropylacryl amide (PNIPAAm) nanoparticles by a novel method including a combination of the UV photopolymerization technique and the liposomal nanoreactors approach, which resulted in homogenous, nanosized PNIPAAm nanoparticles, gelatin/PNIPAAm hydrogels were prepared. An investigation of the effect of monomer, crosslinking agent, and nanoparticle concentrations to gelatin weight percent on the morphology, size, structure, phase transition temperature, swelling, and biodegradability of the nanocomposite hydrogels were carried out. The response surface method (RSM) was used to develop models for predicting and optimizing the hydrogels. Fourier-transform infrared spectroscopy (FTIR) spectra of the monomer, polymers, and nanocomposites indicated the incorporation of the poly N-isopropylacrylamid (PNIPAAm) nanoparticles and gelatin in the structure. Based on scanning electron microscope (SEM) images and dynamic light scattering (DLS) results, the size of the nanoparticles was 250–300 nm which were dispersed well in the gelatin hydrogel. In addition, the nanocomposites showed 80–110% swelling in water, a phase transition temperature (LCST) around 32.5 °C and a biodegradation capability under physiological conditions.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,107.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.