67
Views
0
CrossRef citations to date
0
Altmetric
Articles

Synthesis and Characterization of Gelatin/Poly N-Isopropylacryl Amide Nanocomposite Hydrogels by Response Surface Methodology

, &
Pages 329-349 | Received 23 Jan 2023, Accepted 03 May 2023, Published online: 30 May 2023

References

  • Lanzalaco, S.; Armelin, E. Poly (N-Isopropylacrylamide) and Copolymers: A Review on Recent Progresses in Biomedical Applications. Gels 2017, 3, 36. DOI: 10.3390/gels3040036.
  • Onaciu, A.; Munteanu, R. A.; Moldovan, A. L.; Moldovan, C. S.; Berindan-Neagoe, I. Hydrogels Based Drug Delivery Synthesis, Characterization and Administration. Pharmaceutics 2019, 11, 432. DOI: 10.3390/pharmaceutics11090432.
  • Ahmed, E. M. Hydrogel: Preparation, Characterization, and Applications: A Review. J Adv Res 2015, 6, 105–121. DOI: 10.1016/j.jare.2013.07.006.
  • Farzinfar, E.; Paydayesh, A. Investigation of Polyvinyl Alcohol Nanocomposite Hydrogels Containing Chitosan Nanoparticles as Wound Dressing. Int. J. Polym. Mater. Polym. Biomater. 2019, 68, 628–638. DOI: 10.1080/00914037.2018.1482463.
  • Nagam, S. P.; Jyothi, A. N.; Poojitha, J.; Aruna, S.; Nadendla, R. R. A Comprehensive Review on Hydrogels. Int. J. Curr. Pharm. Res. 2016, 8, 19–23. DOI: 10.22159/ijcpr.2021v13i1.40823.
  • Sharma, S.; Tiwari, S. A Review on Biomacromolecular Hydrogel Classification and Its Applications. Int. J. Biol. Macromol. 2020, 162, 737–747. DOI: 10.1016/j.ijbiomac.2020.06.110.
  • Mahinroosta, M.; Jomeh Farsangi, Z.; Allahverdi, A.; Shakoori, Z. Hydrogels as Intelligent Materials. A Brief Review of Synthesis, Properties and Applications. Mater Today Chem 2018, 8, 42–55. DOI: 10.1016/j.mtchem.2018.02.004.
  • Klouda, L.; Mikos, A. G. Thermoresponsive Hydrogels in Biomedical Applications – a Review. Eur. J. Pharm. Biopharm. 2008, 68, 34–45. DOI: 10.1016/j.ejpb.2007.02.025.
  • Chatterjee, S.; Hui, P.; Kan, C-w Thermoresponsive Hydrogels and Their Biomedical Applications: Special Insight into Their Applications in Textile Based Transdermal Therapy. Polymers 2018, 10, 480. DOI: 10.3390/polym10050480.
  • Foox, M.; Zilberman, M. Drug Delivery from Gelatin-Based Systems. Expert Opin. Drug. Deliv. 2015, 12, 1547–1563. DOI: 10.1517/17425247.2015.1037272.
  • Bakravi, A.; Ahamadian, Y.; Hashemi, H.; Namazi, H. Synthesis of Gelatin-Based Biodegradable Hydrogel Nanocomposite and Their Application as Drug Delivery Agent. Adv. Polym. Technol. 2018, 37, 2625–2635. DOI: 10.1002/adv.21938.
  • Ibusuki, S.; Fujii, Y.; Iwamoto, y.; Matsuda, T. Tissue-Engineered Cartilage Using an Injectable and in-Situ Gelable Thermoresponsive Gelatin: Fabrication and in Vitro Performance. Tissue Eng. 2003, 9, 371–384. DOI: 10.1089/107632703764664846.
  • Rafieian, S.; Mirzadeh, H.; Mahdavi, H.; Masoumi,.; M.; E. A Review on Nanocomposite Hydrogels and Their Biomedical Applications. Sci. Eng. Compos. Mater. 2019, 26, 154–174. DOI: 10.1515/secm-2017-0161.
  • Parsa, P.; Paydayesh, A.; Davachi, S. M. Investigating the Effect of Tetracycline Addition on Nanocomposite Hydrogels Based on Polyvinyl Alcohol and Chitosan Nanoparticles for Specific Medical Applications. Int. J. Biol. Macromol. 2019, 121, 1061–1069. DOI: 10.1016/j.ijbiomac.2018.10.074.
  • Nagase, K.; Yamato, M.; Kanazawa, H.; Okano, T. Poly (N-Isopropylacrylamide)-Based Thermoresponsive Surfaces Provide New Types of Biomedical Applications. Biomaterials 2018, 153, 27–48. DOI: 10.1016/j.biomaterials.2017.10.026.
  • Jafari, M.; Kaffashi, B. Synthesis and Characterization of a Novel Solvent Free dextran-HEMA-PNIPAM Thermosensitive Nanogels. JMS-PAC 2016, 53, 68–74. DOI: 10.1080/10601325.2016.1120173.
  • Seddiki, N.; Aliouche, D. Synthesis, Rheological Behavior and Swelling Properties of Copolymer Hydrogels Based on Poly (n-Isopropylacrylamide) with Hydrophilic Monomers. Bull. Chem. Soc. Eth. 2013, 27, 447–457. DOI: 10.4314/bcse.v27i3.14.
  • Ooi, H. W.; Jack, K. S.; Peng, H.; Whittaker, A. K. “Click” PNIPAAm Hydrogels- a Comprehensive Study of Structure and Properties. Polym. Chem. 2013, 4, 4788–4800. DOI: 10.1039/c3py00653k.
  • Abdul Haq, M.; Su, Y.; Wang, D. Mechanical Properties of PNIPAM Based Hydrogels: A Review. Mater. Sci. Eng. C 2017, 70, 842–855. DOI: 10.1016/j.msec.2016.09.081.
  • Ziminska, M.; Wilson, J. J.; McErlean, E.; Dunne, N.; McCarthy, H. O. Synthesis and Evaluation of a Thermoresponsive Degradable Chitosan-Grafted PNIPAAm Hydrogel as a “Smart” Gene Delivery System. Materials 2020, 13, 2530. DOI: 10.3390/ma13112530.
  • Zhang, X. Z.; Wu, D. Q.; Chu, C. C. Synthesis, Characterization and Controlled Drug Release of Thermosensitive IPN-PNIPAAm Hydrogels. Biomaterials 2004, 25, 3793–3805. DOI: 10.1016/j.biomaterials.2003.10.065.
  • Ohya, S.; Kidoaki, S.; Matsuda, T. Poly (N-Isopropylacrylamide)(PNIPAM)-Grafted Gelatin Hydrogel Surfaces: Interrelationship between Microscopic Structure and Mechanical Property of Surface Regions and Cell Adhesiveness. Biomaterials 2005, 26, 3105–3111. DOI: 10.1016/j.biomaterials.2004.08.006.
  • Ohya, S.; Matsuda, T. Poly (N-Isopropylacrylamid)(PNIPAAm)-Grafted Gelatin as Thermoresponsive Three-Dimensional Artificial Extracellular Matrix: Molecular and Formulation Parameters vs. cell Proliferation Potential. J. Biomater. Sci. Polym. Ed. 2005, 16, 809–827. DOI: 10.1163/1568562054255736.
  • Ohya, S.; Sonoda, H.; Nakayama, Y.; Matsuda, T. The Potential of Poly (N-Isopropylacrylamide) (PNIPAM)-Grafted Hyaluronan and PNIPAM-Grafted Gelatin in the Control of Post-Surgical Tissue Adhesions. Biomaterials 2005, 26, 655–659. DOI: 10.1016/j.biomaterials.2004.03.002.
  • Ohya, S.; Nakayama, Y.; Matsuda, T. In Vivo Evaluation of Poly (N-Isopropylacrylamide) (PNIPAM)-Grafted Gelatin as an in Situ-Formable Scaffold. J. Artif. Organs. 2004, 7, 181–186. DOI: 10.1007/s10047-004-0265-9.
  • Morikawa, N.; Matsuda, T. Thermoresponsive Artificial Extracellular Matrix: N-Isopropylacrylamide-Graft-Copolymerized Gelatin. J. Biomater. Sci. Polym. Ed. 2002, 13, 167–183. DOI: 10.1163/156856202317414357.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.