Publication Cover
Spectroscopy Letters
An International Journal for Rapid Communication
Volume 26, 1993 - Issue 10
24
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

NMR Studies of Drugs. Phensuximide. 1H and 13C NMR Methods with Chiral Solvating Agents and Lanthanide Shift Reagents

, &
Pages 1997-2015 | Received 30 Jun 1993, Accepted 09 Aug 1993, Published online: 23 Sep 2006

References

  • Aboul-Enein , H. Y. 1988 . NMR methods for optical purity determination of pharmaceuticals. . Anal. Lett. , 21 ( 12 ) : 2155 – 2163 .
  • Pirkle , W. H. and Hoover , D. J. 1982 . “ Topics in Stereochemistry ” . In NMR chiral solvating agents. , Edited by: Eliel , E. L. , Allinger , N. L. and Wilen , S. H. Vol. 13 , 263 – 331 . New York : Wiley-Interscience . and references cited therein
  • Weisman , G. R. 1983 . “ Asymmetric Synthesis ” . In Nuclear magnetic resonance analysis using chiral solvating agents. , Edited by: Morrison , J. D. Vol. 1 , 153 – 171 . New York, London : Academic Press .
  • Wenzel , T. J. 1987 . NMR Shift Reagents , Boca Raton, FL : CRC Press .
  • Cockerill , A. F. , Davies , G. L. O. , Harden , R. C. and Rackham , D. M. 1973 . Lanthanide shift reagents for nuclear magnetic resonance spectroscopy. . Chem. Rev. , 73 ( 6 ) : 553 – 588 .
  • Morrill , T. C. , ed. 1986 . Lanthanide Shift Reagents in Stereochemical Analysis. , New York : VCH .
  • Reifsneider , R. J. Jr. , Hoffman , B. H. , Venkatasubban , K. S. and Rothchild , R. 1991 . NMR studies of drugs. Application of a chiral lanthanide shift reagent for potential direct determination of enantiomeric excess of methsuximide. . Spectrosc. Lett. , 24 ( 10 ) : 1373 – 1394 .
  • Rothchild , R. , Braddock , S. , Sanders , K. , Traviglia , S. and Venkatasubban , K. S. 1993 . NMR studies of drugs. Achiral and chiral lanthanide shift reagents with mephenoxalone a substituted z-oxazolidinone. . Spectrosc. Lett. , 26 ( 2 ) : 271 – 291 .
  • Rothchild , R. , Braddock , S. , Traviglia , S. and Venkatasubban , K. S. 1993 . NMR studies of drugs. 5-Methyl-5-phenylhydantoin. Applications of lanthanide shift reagents in polar solvents to a non-chelating substrate. . Spectrosc. Lett. , 26 ( 3 ) : 411 – 430 .
  • Keller , L. and Rothchild , R. 1992 . NMR studies of drugs. Applications of achiral and chiral lanthanide shift reagents to α-ethyl-α-phenylsuccinimide. . Spectrosc. Lett. , 25 ( 8 ) : 1177 – 1197 .
  • Rothchild , R. , Sanders , K. and Venkatasubban , K. S. 1993 . NMR studies of drugs. Use of lanthanide shift reagents in polar solvent with thalidomide. . Spectrosc. Lett. , 26 ( 4 ) : 597 – 619 .
  • Avolio , J. , Thomson Eberhart , S. , Rothchild , R. and Simons , P. 1986 . 1H NMR spectral simplification with achiral and chiral lanthanide shift reagents. Pt. II: Ethosuximide, 3-ethyl-3-methyl-2,5-pyrrolidinedione, and comparisons with analogs. . Appl. Spectrosc. , 40 ( 4 ) : 531 – 537 .
  • Armstrong , D. W. , Stalcup , A. M. , Hilton , M. L. , Duncan , J. D. , Faulkner , J. R. Jr. and Chang , S.-C. 1990 . Derivatized cyclodextrins for normal-phase liquid chromatographic separation of enartiomers. . Anal. Chem. , 62 ( 15 ) : 1610 – 1615 .
  • Yang , Z.-Y. , Barkan , S. , Brunner , C. , Weber , J. D. , Doyle , T. D. and Wainer , I. W. 1985 . Application of high-performance liquid chromatographic chiral stationary phases to pharmaceutical analysis. Resolution of enantiomeric barbiturates succinimides and related molecules on four commercially available chiral stationary phases. . J. Chromatogr. , 324 : 444 – 449 .
  • Turczan , J. W. and Goldwitz , B. A. 1973 . NMR analysis of Pharmaceuticals. X: Determination of methsuximide and phensuximide in capsules. . J. Pharm. Sci. , 62 ( 10 ) : 1705 – 1707 .
  • Nuhn , P. , Zschunke , A. and Woitkowitz , P. 1973 . 1H-NMR-spektroskopische untersuchung einiger antiepileptica. 4. Mitteilung: NMR-spektroskopie von arzneimitteln. . Pharmazie , 28 ( 7 ) : 484 – 485 .
  • Wenzel , T. J. , Morin , C. A. and Brechting , A. A. 1992 . Lanthanidechiral resolving agent mixtures as chiral NMR shift reagents. . J. Org. Chem. , 57 ( 13 ) : 3594 – 3599 .
  • Myers , C. and Rothchild , R. unpublished results
  • Hoffman , B. H. and Venkatasubban , K. S. unpublished results
  • Hawkes , G. E. , Marzin , C. , Leibfritz , D. , Johns , S. R. , Herwig , K. , Cooper , R. A. , Roberts , D. W. and Roberts , J. D. 1973 . “ Lanthanideinduced 13C NMR shifts. ” . In Nuclear Magnetic Resonance Shift Reagents. , Edited by: Sievers , R. E. 129 – 142 . New York : Academic Press .
  • Breitmaier , E. and Voelter , W. 1987 . Carbon-13 NMR Spectroscopy , 3rd ed. , 123 – 127 . New York : VCH . esp.
  • McConnell , H. M. and Robertson , R. E. 1958 . Isotropic nuclear resonance shifts. . J. Chem. Phys. , 29 ( 6 ) : 1361 – 1365 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.