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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 18
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Original Articles

Microwave‐Assisted Synthesis and Antiprotozoal Activity of Pyridazines Carrying Polyfluoro Substituents

, , &
Pages 2719-2725 | Received 03 Feb 2006, Published online: 16 Feb 2007
 

Abstract

A number of 4,5‐dichloro‐ and 4,5‐dibromopyridazin‐3‐ones and ‐3,6‐diones with polyfluoro substituents at position 2 were obtained in good yields by microwave‐assisted method. The oxopyridazines as well as their respective 5‐dimethylaminoethylamino derivatives were tested for antibacterial, antiviral, and antiprotozoal activity.

Acknowledgments

The study was supported by the Foundation for Development Diagnostics and Therapy, Warsaw, Poland. The authors are grateful to S. J. Chrapusta for his critical reading of the manuscript

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