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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 8
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Original Articles

N‐Glycosyl‐N′‐[p‐(isoamyloxy)phenyl]‐thiourea Derivatives: Potential Anti‐TB Therapeutic Agents

Avraham Liav Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USACorrespondence[email protected]
,
Shiva K. Angala Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA
&
Patrick J. Brennan Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA
Pages 1176-1183 | Received 30 Oct 2007, Published online: 17 Apr 2008
 
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Abstract

Thiocarlide (THC; N,N′‐bis[p‐(isoamyloxy)phenyl]‐thiourea; also known as Isoxyl®) has been used in the past as an anti‐tuberculosis agent. In an effort to improve the therapeutic value of THC, several N‐glycosyl‐N′‐[p‐(isoamyloxy)phenyl]‐thiourea derivatives were synthesized by coupling an aniline derivative and glycosyl isothiocyanates. The minimum inhibitory concentration (MIC) values of the new products against M. tuberculosis were determined.

Acknowledgment

The work was supported by Grant RO1 AI063054 from the National Institute of Allergy and Infectious Diseases, National Instiute of Health (NIH).

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