Synthesis and in Vitro Antimicrobial Activity of 3-Aryl-4-S-benzyl-6-phenylimino-2-hepta-O-acetyl-β-D-lactosylimino-2,3-dihydro-1,3,5-thiadiazine (Hydrochloride)

Abstract

The present work includes synthesis of several 3-aryl-4-S-benzyl-6-phenylimino-2-hepta-O-acetyl-β-D-lactosylimino-2,3-dihydro-1,3,5-thiadiazines (hydrochloride) by the interaction of N-hepta-O-acetyl-β-D-lactosyl isocyanodichloride and 1-aryl-5-phenyl-2-S-benzyl-2,4-isodithiobiurets. All these products have been characterized through the usual chemical transformations and infrared, ¹H NMR, and mass spectral analysis. The compounds were also screened for their antimicrobial activities.

GRAPHICAL ABSTRACT

Keywords:

• Isodithiobiurets
• lactosyl isocyanodichloride
• thiadiazines

ACKNOWLEDGMENTS

The authors acknowledge SAIF, CDRI, Lucknow, for providing the spectral data. They are also thankful to the principal, S. G. Bhadange, for encouragement and the necessary facilities.

Notes

^a Including the well diameter of 5 mm.

Note: Zone of inhibition in mm.