Abstract
New cis-N-alkyl-1,3-oxazolidin-2-ones were prepared in moderate to good yields via phosgenation of erythro-1,2-aminoalcohol monoesters, accompanied by formation of aziridine by-products. On the other hand, their regioisomers trans-N-alkyl-1,3-oxazolidin-2-ones were prepared regio- and stereoselectively in good yields by ring expansion of trans-N-alkyl aziridine-2-carboxylates.
GRAPHICAL ABSTRACT
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ACKNOWLEDGMENT
We thank N. Gabsi for interesting and valuable English discussions.
Notes
a Yields refer to isolated chromatographically pure compounds.
a Yields refer to isolated chromatographically pure compounds.