Green Process Development for the Synthesis of Aliphatic Symmetrical N,N′-Disubstituted Thiourea Derivatives in Aqueous Medium

GRAPHICAL ABSTRACT

Abstract

A highly efficient green process for the synthesis of N,N′-disubstituted aliphatic thiourea derivatives using primary aliphatic amines and carbon disulfide in an aqueous medium at room temperature via a nonisothiocyanate route is described. This protocol illustrates the rapid preparation of N,N′-disubstituted aliphatic thiourea derivatives in excellent yields with some advantages such as no catalyst and simple workup without any side product formation. Moreover, the new route is concise, does not require chromatography, and is adaptable to pilot-scale preparation.

Keywords:

• Amine
• carbon disulfide
• catalyst free
• 1,3-disubstituted thioureas
• green synthesis
• water

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ACKNOWLEDGMENTS

The authors are thankful to University of Pune and SAIF, Punjab University, Chandigarh, for providing the spectral analysis.

SUPPORTING INFORMATION

Supplementary material, which includes some of the scan copies of IR, ¹H NMR, ¹³C NMR, and mass analyses for this article, can be accessed on the publisher's website.