A simple method for the synthesis of sulfonic esters

Abstract

An efficient and simple approach for the direct synthesis of aryl and heteroaryl sulfonic esters was developed using DMS and DES as alkoxysulfonylation reagents. The reaction is operationally simple and scalable. This protocol does not require solvent, expensive catalysts, base, ligand additives or other reagents. A wide range of sulfonic esters were synthesized in moderate to good chemical yields. This method has the advantage of low cost, facile and tolerated a wide range of substrates.

Graphical Abstract

Keywords:

• Dimethyl sulfate
• diethyl sulfate
• sulfonic esters
• solvent-free synthesis
• catalyst-free synthesis

Acknowledgments

The authors are grateful to Suven Life Sciences management for allowing us to publish these results.