Abstract
A convenient and eco-friendly, one-pot synthetic protocol for pharmaceutically important pyran-based heterocyclic compounds is repeated herein. The reactions were carried out at room temperature in a water–ethanol solvent mixture under direct irradiation of UV365 light source in the absence of photocatalyst. The merits of the present protocol include mild and catalyst-free reactions, green procedures, and high yields. The added advantage of this protocol is that it can be applied for large-scale synthesis of various pyran-based heterocyclic compounds without employing any expensive catalyst. Also, in vitro antibacterial screening of pyran derivative was investigated against both Gram-positive Bacillus cereus (B. cereus) and Gram-negative bacteria Escherichia coli (E. coli).
Graphical Abstract
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Acknowledgments
The authors would like to acknowledge Dr. M. K. Sahoo for allowing the use of the UV photoreactor. SAIF-NEHU, Department of Chemistry-NEHU, and CDRI Lucknow are highly acknowledged for providing various analytical assistance. The support from Prof. Dhruva Kumar Jha (Gauhati University) is gratefully acknowledged.
Disclosure statement
No potential conflict of interest was reported by the author(s).