An efficient synthesis of pyrazolylbarbiturates by three-component reaction between barbituric/thiobarbituric acid, aroylphenylhydrazones and arylglyoxals

Abstract

An effective protocol for synthesis of some new pyrazolylbarbiturate derivatives is reported through a one-pot, three-component reaction between barbituric/thiobarbituric acid, aroylphenylhydrazones and arylglyoxal derivatives. All reactions were conducted in ethanol as solvent without using any catalyst and products were obtained by simple filtering of the precipitated solids in high yields. All products were characterized by ¹H and ¹³C NMR and IR spectral and elemental analysis data.

Graphical Abstract

Keywords:

• Arylglyoxals
• aroylphenylhydrazones
• barbituric acid
• pyrazolylbarbiturates
• thiobarbituric acid
• three-component reaction

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper