Polymeric nanomicelles for cancer theragnostics

ABSTRACT

Recently, interdisciplinary research in cancer diagnosis and therapy has evolved to the point where nanotechnology particularly polymeric nanodelivery systems are utilized for theragnostic applications. Nanoscale are being trialed for specific targeted delivery of drugs, micelles, antibody, DNA, protein, etc. to cancer sites to improve the therapeutic efficacy due to improved distribution specificity, increased internalization, and intracellular drug delivery that minimize the side effects. Polymeric micelles have been subjected to extensive studies in the field of drug delivery, functioning as drug solubilizers and carriers. More recently, a micelle constructed as a hybrid from hydrophilic oligonucleotide and hydrophobic polymer has drawn close attention. Mostly used micelles are synthesized with polymer and have several physical properties, including molecular weight and copolymer block composition, which can be tailored to alter the vesicle structure. In this review, we focused on the different polymeric nanodelivery systems is association with different type of cancer therapeutics such as micelles, drug, aptamer, DNA, recombinant protein, miRNA, siRNA, small inhibitors, gene, antibody, proteins and some conjugating molecules that involved in cancer therapy have been discussed.

GRAPHICAL ABSTRACT

KEYWORDS:

• Biopolymers
• nanoantibody
• nanoaptamer
• nanodelivery
• nanogene
• nanomicelles

Acknowledgments

The authors thank Amrita Centre for Nanosciences and Molecular Medicine for the infrastructure support.