Polymeric nanomicelles for cancer theragnostics

References

• Sanna, V.; Pala, P.; Dessì, G.; Manconi, P.; Mariani, A.; Dedola, S.; Rassu, M.; Crosio, C.; Laccarino, C.; Sechi, M. Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities. Int. J. Nanomed. 2014, 9, 4935–4951.
   PubMed Web of Science ®Google Scholar
• Singh, R.; Lillard, J. W. Nanoparticle-based targeted drug delivery. Exp. Mol. Pathol. 2009, 86, 215–223.
   PubMed Web of Science ®Google Scholar
• Katragadda, U.; Fan, W.; Wang, Y.; Teng, Q.; Tan, C. Combined delivery of paclitaxel and tanespimycin via micellar nanocarriers: Pharmacokinetics, efficacy and metabolomic analysis. PLoS ONE 2013, 8, e58619.
   PubMed Web of Science ®Google Scholar
• Wu, Y.; Sefaha, K.; Liua, H.; Wanga, R.; Tana, W. DNA aptamer–micelle as an efficient detection/delivery vehicle toward cancer cells. PNAS 2010, 107, 5–10.
   PubMed Web of Science ®Google Scholar
• Kim, S.; Shi, Y.; Kim, J. Y.; Park, K.; Cheng, J.-X. Overcoming the barriers in micellar drug delivery: Loading efficiency, in vivo stability, and micelle–cell interaction. Expert Opin. Drug Deliv. 2010, 7, 49–62.
   PubMed Web of Science ®Google Scholar
• Lin, C.-Y.; Hsiao-Ching, T.; Heng-Ruei, S.; Ming-Fang, W.; Cheng-Ying, C.; Win-Li, L. Ultrasound sonication with microbubbles disrupts blood vessels and enhances tumor treatments of anticancer nanodrug. Int. J. Nanomed. 2012, 7, 2143–2152.
   PubMed Web of Science ®Google Scholar
• Juan-Juan, Y.; Sonali, S.; Stepan, P. S.; Zhi-Xin, W.; Zhi-Wei, Z.; Yangde, Z.; Peixuan, G.; Chen-Zhong, L.; Jagat, R. K.; Tianxin, Y.; Shyam, S. M.; Wanqing, L.; Wei, D.; Jian-Cheng, W.; Qi, L.; Xueji, Z.; Jun, T.; Lee, J.; Jun, L.; Ming, Q. W.; Xiaotian, L.; Shu-Feng, Z. Synthesis and biological evaluation of novel folic acid receptor-targeted, b-cyclodextrin-based drug complexes for cancer treatment. PLoS ONE 2013, 8, e62289.
   PubMed Web of Science ®Google Scholar
• Karvea, S.; Wernera, M. E.; Sukumar, R.; Cummings, N. D.; Coppa, J. A.; Wang, E. C.; Lic, C.; Sethia, M.; Chend, R. C.; Pacolde, M. E.; Wang, A. Z. Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery. PNAS 2012, 109, 8230–8235.
   PubMed Web of Science ®Google Scholar
• Bhirde, A. A.; Kapoor, A.; Liu, G.; Iglesias-Bartolome, R.; Jin, A.; Zhang, G.; Xing, R.; Lee, S.; Leapman, R. D.; Gutkind, J. S.; Chen, X. Nuclear mapping of nano-drug delivery systems in dynamic cellular environments. ACS Nano 2012, 6, 4966–4972.
   PubMed Web of Science ®Google Scholar
• Spänkuch, B.; Steinhauser, I.; Wartlick, H.; Kurunci-Csacsko, E.; Strebhardt, K. I.; Langer, K. Downregulation of Plk1 expression by receptor-mediated uptake of antisense oligonucleotide-loaded nanoparticles. Neoplasia 2008, 10, 223–234.
   PubMed Web of Science ®Google Scholar
• Chen, Y.; Yang, L.; Huang, S.; Li, Z.; Zhang, L.; He, J.; Xu, Z.; Liu, L.; Cao, Y.; Sun, L. Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model. Int. J. Nanomed. 2013, 8, 3107–3118.
   PubMed Web of Science ®Google Scholar
• Prijic, S.; Prosen, L.; Cemazar, M.; Scancar, J.; Romih, R.; Lavrencak, J.; Bregar, V. B.; Coer, A.; Krzan, M.; Znidarsic, A.; Sersa, G. Surface modified magnetic nanoparticles for immuno-gene therapy of murine mammary adenocarcinoma. Biomaterials 2012, 33, 4379–4391.
   PubMed Web of Science ®Google Scholar
• Kievit, F. M.; Veiseh, O.; Fang, C.; Bhattarai, N.; Lee, D.; Ellenbogen, R. G.; Zhang, M.; Zhang, M. Chlorotoin labeled magnetic nanovectors for targeted gene delivery to glioma. ACS Nano 2012, 4, 4587–4594.
   Web of Science ®Google Scholar
• Li, W.; Li, H.; Li, J.; Wang, H.; Zhao, H.; Zhang, L.; Xia, Y.; Ye, Z.; Gao, J.; Dai, J.; Wang, H.; Guo, Y. Self-assembled supramolecular nano vesicles for safe and highly efficient gene delivery to solid tumors. Int. J. Nanomed. 2012, 7, 4661–4677.
   PubMed Web of Science ®Google Scholar
• Zhang, Y.; Chen, Y.; Han, D.; Ocsoy, I.; Tan, W. Aptamers selected by cell-SELEX for application in cancer studies. Bioanalysis 2010, 2, 907–918.
   PubMed Web of Science ®Google Scholar
• Meng, L.; Yang, L.; Zhao, X.; Zhang, L.; Zhu, H.; Liu, C.; Tan, W. Targeted delivery of chemotherapy agents using a liver cancer-specific aptamer. PLoS ONE 2012, 7, e33434.
   PubMed Web of Science ®Google Scholar
• Hasan, W.; Chu, K.; Gullapalli, A.; Dunn, S. S.; Enlow, E. M.; Luft, J. C.; Tian, S.; Napier, M. E.; Pohlhaus, P. D.; Rolland, J. P.; DeSimone, J. M. Delivery of multiple siRNAs using lipid-coated PLGA nanoparticles for treatment of prostate cancer. Nano Lett. 2012, 12, 287–292.
   PubMed Web of Science ®Google Scholar
• Butt, A. M.; Mohd Amin, M. C.; Katas, H. Synergistic effect of pH-responsive folate functionalized poloxamer 407-TPGS-mixed micelles on targeted delivery of anticancer drugs. Int. J. Nanomed. 2015, 10, 1321–1334.
   PubMed Web of Science ®Google Scholar
• Danafar, H.; Davaran, S.; Rostamizadeh, K.; Valizadeh, H.; Hamidi, M. Biodegradable mPEG/PCL core-shell micelles: Preparation and characterization as a sustained release formulation for curcumin. Adv. Pharm. Bull. 2014, 4, 501–510.
   PubMedGoogle Scholar
• Callahan, D. J.; Liu, W.; Li, X.; Dreher, M. R.; Hassouneh, W.; Kim, M.; Marszalek, P.; Chilkoti, A. Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution. Nano Lett. 2012, 2, 2165–2170.
   Web of Science ®Google Scholar
• Lian, H.; Sun, J.; Yu, Y. P.; Liu, Y. H.; Cao, W.; Wang, Y. J. Supramolecular micellar nano-aggregates based on a novel chitosan/vitamin E succinate copolymer for paclitaxel selective delivery. Int. J. Nanomed. 2011, 6, 3323–3334.
   PubMed Web of Science ®Google Scholar
• Tang, R.; Ji, W.; Panus, D.; Palumbo, R. N.; Wang, C. Block copolymer micelles with acid-labile ortho ester sidechains: Synthesis, characterization, and enhanced drug delivery to human glioma cells. J. Control Release 2011, 151, 18–27.
   PubMed Web of Science ®Google Scholar
• Liu, X.; Cui, W.; Li, B.; Hong, Z. Targeted therapy for glioma using cyclic RGD-entrapped polyionic complex nanomicelles. Int. J. Nanomed. 2012, 7, 2853–2862.
   PubMed Web of Science ®Google Scholar
• Rubinstein, I.; Soos, I.; Onyuksel, H. Intracellular delivery of VIP-grafted sterically stabilized phospholipid mixed nanomicelles in human breast cancer cells. Chem. Biol. Interact. 2008, 171, 190–194.
   PubMed Web of Science ®Google Scholar
• Onyuksel, H.; Mohanty, P. S.; Rubinstein, I. Vip-grafted sterically stabilized phospholipid nanomicellar 17-allylamino-17-demethoxy geldanamycin: A novel targeted nanomedicine for breast cancer. Int. J. Pharm. 2009, 365, 157–161.
   PubMed Web of Science ®Google Scholar
• Liu, K. K.; Zheng, W. W.; Wang, C. C.; Chiu, Y. C.; Cheng, C. L.; Lo, Y. S.; Chen, C.; Chao, J. I. Covalent linkage of nanodiamond-paclitaxel for drug delivery and cancer therapy. Nanotechnology 2010, 21, 315106.
   PubMed Web of Science ®Google Scholar
• Rios-Doria, J.; Carie, A.; Costich, T.; Burke, B.; Skaff, H.; Panicucci, R.; Sill, K. A versatile polymer micelle drug delivery system for encapsulation and in vivo stabilization of hydrophobic anticancer drugs. J. Drug Deliv. 2012, 2012, 951741.
   PubMedGoogle Scholar
• Tan, C.; Wang, Y.; Fan, W. Exploring polymeric micelles for improved delivery of anticancer agents: Recent developments in preclinical studies. Pharmaceutics 2013, 5, 201–219.
   PubMedGoogle Scholar
• Jin, J.; Sui, B.; Gou, J.; Liu, J.; Tang, X.; Xu, H.; Zhang, Y.; Jin, X. PSMA ligand conjugated PCL-PEG polymeric micelles targeted to prostate cancer cells. PLoS ONE 2014, 9, e112200.
   PubMed Web of Science ®Google Scholar
• Liu, P.; Situ, J. Q.; Li, W. S.; Shan, C. L.; You, J.; Yuan, H.; Hu, F. Q.; Du, Y. Z. High tolerated paclitaxel nano-formulation delivered by poly (lactic-co-glycolic acid)-g-dextran micelles to efficient cancer therapy. Nanomedicines 2015, 11, 855–866.
   PubMed Web of Science ®Google Scholar
• Bushman, J.; Vaughan, A.; Sheihet, L.; Zhang, Z.; Costache, M.; Kohn, J. Functionalized nanospheres for targeted delivery of paclitaxel. J. Control. Release 2013, 171, 315–321.
   PubMed Web of Science ®Google Scholar
• Snima, K. S.; Jayakumar, R.; Unnikrishnan, A. G.; Nair, S. V.; Lakshmanan, V.-K. O-Carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells. Carbohydr. Polym. 2012, 89, 1003–1007.
   PubMed Web of Science ®Google Scholar
• Snima, K. S.; Jayakumar, R.; Lakshmanan, V.-K. In vitro and in vivo biological evaluation of O-carboxymethyl chitosan encapsulated metformin nanoparticles for pancreatic cancer therapy. Pharm. Res. 2014, 31(12), 3361–3370.
   PubMed Web of Science ®Google Scholar
• Snima, K. S.; Nair, R. S.; Nair, S. V.; Kamath, C. R.; Lakshmanan, V. K. Combination of anti-diabetic drug metformin and boswellic acid nanoparticles: A novel strategy for pancreatic cancer therapy. J. Biomed. Nanotechnol. 2015, 11(1), 93–104.
   PubMed Web of Science ®Google Scholar
• Snima, K. S.; Arunkumar, P.; Nair, S. V.; Jayakumar, R.; Lakshmanan, V.-K. Silymarin encapsulated PLGA nanoparticles: A prospective candidate for prostate cancer therapy. J. Biomed. Nanotechnol. 2013, 9, 1–12.
   PubMed Web of Science ®Google Scholar
• Uthaman, S.; Snima, K. S.; Annapoorna, M.; Ravindranath, K. C.; Shanti, V. N.; Lakshmanan, V.-K. Novel boswellic acids nanoparticles induces cell death in prostate cancer cells. J. Nat. Prod. 2012, 5, 100–108.
   Google Scholar
• Cherian, A. M.; Nair, S. V.; Lakshmanan, V.-K. The role of nanotechnology for prostate cancer theranostic applications. J. Nanosci. Nanotechnol. 2014, 14, 841–852.
   PubMed Web of Science ®Google Scholar
• Shao, J.; Griffin, R. J.; Galanzha, E. I.; Kim, J.-W.; Koonce, N.; Webber, J.; Mustafa, T.; Biris, A. S.; Nedosekin, D. A.; Zharov, V. P. Photothermal nanodrugs: Potential of TNF-gold nanospheres for cancer theranostics. Sci. Rep. 2013, 3, 1293.
   PubMed Web of Science ®Google Scholar
• Bocci, G.; Fioravanti, A.; Orlandi, P.; Desidero, T. D.; Natale, G.; Fanelli, G.; Viacava, P.; Naccarato, A. G.; Francia, G.; Danesi, R. Metronomic ceramide analogs inhibit angiogenesis in pancreatic cancer through up-regulation of caveolin-1 and thrombospondin-1 and down-regulation of cyclin D1. Neoplasia 2012, 14, 833–845.
   PubMed Web of Science ®Google Scholar
• Lin, J.; Yu, Y.; Shigdar, S.; Fang, D. Z.; Du, J. R.; Wei, M. Q.; Danks, A.; Liu, K.; Duan, W. Enhanced antitumor efficacy and reduced systemic toxicity of sulfatide-containing nanoliposomal doxorubicin in a xenograft model of colorectal cancer. PLoS ONE 2012, 7, e49277.
   PubMed Web of Science ®Google Scholar
• Inoue, S.; Ding, H.; Portilla-Arias, J.; Hu, J.; Kond, B.; Fujita, M.; Espinoza, A.; Suhane, S.; Riley, M.; Gates, M.; Patil, R.; Penichet, M. L.; Ljubimov, A. V.; Black, K. L.; Holle, E.; Ljubimova, J. Y. Polymalic acid–based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity. Cancer Res. 2011, 71, 1454–1464.
   PubMed Web of Science ®Google Scholar
• Ding, H.; Helguera, G.; Rodríguez, J. A.; Markmana, J.; Luria-Pérezb, R.; Gangaluma, P.; Portilla-Ariasa, J.; Inouea, S.; Daniels-Wellsb, T. R.; Black, K.; Holler, E.; Penichet, M. L.; Ljubimova, J. L. Polymalic acid nanobioconjugate for simultaneous inhibition of tumor growth and immunostimulation in HER2/neu-positive breast cancer. J. Control. Release 2013, 171, 322–329.
   PubMed Web of Science ®Google Scholar
• Chandran, S.; Praveen, G.; Snima, K. S.; Nair, S. V.; Pavithran, K.; Chennazhi, K.; Lakshmanan, V.-K. Potential use of drug loaded nano composite scaffolds for the treatment of ovarian cancer. J. Curr. Drug Deliv. 2013, 10, 326–335.
   PubMed Web of Science ®Google Scholar
• Anitha, A.; Uthaman, S.; Nair, S. V.; Jayakumar, R.; Lakshmanan, V.-K. Enhanced delivery system of flutamide loaded chitosan-dextran sulphate nanoparticles for prostate cancer. J. Biomed. Nanotechnol. 2013, 3, 335–347.
   Web of Science ®Google Scholar
• Snima, K. S.; Sreelakshmi, K. V.; Renu, G.; Nair, S. V.; Subramanian, K. R. V.; Lakshmanan, V.-K. Development of activated carbon-ceria nanocomposite materials for prostate cancer. Therapy Adv. Sci. Eng. Med. 2013, 5, 1132–1136.
   Google Scholar
• Renu, G.; Rani, V. V. D.; Nair, S. V.; Subramanian, K. R. V.; Lakshmanan, V.-K. Development of cerium oxide nanoparticles and its cytotoxicity in prostate cancer cells. Adv. Sci. Lett. 2012, 6, 17–25.
   Google Scholar
• Lakshmanan, V.-K.; Bumgardner, J. D.; Nair, S. V.; Jayakumar, R. Chitosan-based nanoparticles in cancer therapy. Adv. Polym. Sci. 2011, 243, 55–91.
   Web of Science ®Google Scholar
• Karuppath, S.; Snima, K. S.; Ravindranath, K. C.; Nair, S. V.; Lakshmanan, V.-K. Anti-proliferative effect of Tinospora cordifolia nanoparticles in prostate cancer cells. J. Bionanosci. 2016, 10, 127–133.
   Google Scholar
• Nandan, C. D.; Reshmi, P.; Utham, S.; Snima, K. S.; Unni, A. K. K.; Kamath, C. R.; Nair, S. V.; Lakshmanan, V.-K. Therapeutic properties of Boswellic acid nanoparticles in prostate tumor-bearing BALB/c mice model. J. Nanopharm. Drug Deliv. 2013, 1, 30–37.
   Google Scholar
• Nair, R. S.; Snima, K. S.; Kamath, R. C.; Nair, S. V.; Lakshmanan, V.-K. Synthesis and characterization of Careya arborea nanoparticles for assessing its in vitro efficacy in pancreatic cancer cells. J. Nat. Prod. 2015, 8, 09–15.
   Google Scholar
• Mohandas, A.; Snima, K. S.; Jayakumar, R.; Lakshmanan, V.-K. Chitosan based AGR2 siRNA nanoparticle delivery system for prostate cancer cells. J. Chitin Chitosan Sci. 2013, 1, 1–5.
   Google Scholar
• Sua, R.; Konga, T.; Zhanga, B.; Songa, Q.; Chenga, G. TiO2/Si core/shell nanowires array as molecule carriers. Proc. Environ. Sci. 2011, 8, 492–497.
   Google Scholar
• Xu, J.; Singh, A.; Amiji, M. M. Redox-responsive targeted gelatin nanoparticles for delivery of combination wt-p53 expressing plasmid DNA and gemcitabine in the treatment of pancreatic cancer. BMC Cancer 2014, 14, 75.
   PubMed Web of Science ®Google Scholar
• Kenny, G. D.; Bienemann, A. S.; Tagalakis, A. D.; Pugh, J. A.; Welser, K.; Campbell, F.; Tabor, A. B.; Hailes, H. C.; Gill, S. S.; Lythgoe, M. F.; McLeod, C. W.; White, E. A.; Hart, S. L. Multifunctional receptor-targeted nanocomplexes for the delivery of therapeutic nucleic acids to the brain. Biomaterials 2013, 34, 9190–9200.
   PubMed Web of Science ®Google Scholar
• Li, G.; Hu, Z.; Yin, H.; Zhang, Y.; Huang, X.; Wang, S.; Li, W. A novel dendritic nanocarrier of polyamidoamine-polyethylene glycol-cyclic RGD for “smart” small interfering RNA delivery; and in vitro antitumor effects by human ether-à-go-go-related gene silencing in anaplastic thyroid carcinoma cells. Int. J. Nanomed. 2013, 8, 1293–1306.
   PubMed Web of Science ®Google Scholar
• Zou, S.; Cao, N.; Cheng, D.; Zheng, R.; Wang, J.; Zhu, K.; Shuai, X. Enhanced apoptosis of ovarian cancer cells via nanocarrier-mediated codelivery of siRNA and doxorubicin. Int. J. Nanomed. 2012, 7, 3823–3835.
   PubMed Web of Science ®Google Scholar
• Biswas, S.; Deshpande, P. P.; Navarro, G.; Dodwadkar, N. S.; Torchilin, V. P. Lipid modified triblock PAMAM-based nanocarriers for siRNA drug co-delivery. Biomaterials 2013, 34, 1289–1301.
   PubMed Web of Science ®Google Scholar
• Chen, Y.; Wang, W.; Lian, G.; Qian, C.; Wang, L.; Zeng, L.; Liao, C.; Liang, B.; Huang, B.; Huang, K.; Shuai, X. Development of an MRI-visible nonviral vector for siRNA delivery targeting gastric cancer. Int. J. Nanomed. 2012, 7, 359–368.
   PubMed Web of Science ®Google Scholar
• Taratula, O.; Garbuzenko, O. B.; Kirkpatrick, P.; Pandya, I.; Savla, R.; Pozharova, V. P.; He, H.; Minko, T. Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery. J Control. Release 2009, 140, 284–293.
   PubMed Web of Science ®Google Scholar
• Mitra, M.; Kandalam, M.; Rangasamy, J.; Shankar, B.; Maheswari, U. K.; Swaminathan, S.; Krishnakumar, S. Novel epithelial cell adhesion molecule antibody conjugated polyethyleneimine-capped gold nanoparticles for enhanced and targeted small interfering RNA delivery to retinoblastoma cells. Mol. Vis. 2013, 19, 1029–1038.
   PubMedGoogle Scholar
• Wu, C.; Gong, F.; Pang, P.; Shen, M.; Zhu, K.; Cheng, D.; Liu, Z.; Shan, H. An RGD-modified MRI-visible polymeric vector for targeted siRNA delivery to hepatocellular carcinoma in nude mice. PLoS ONE 2013, 8, e66416.
   PubMed Web of Science ®Google Scholar
• Saraswathy, M.; Gong, S. Recent developments in the co-delivery of siRNA and small molecule anticancer drugs for cancer treatment. Mater. Today 2014, 17, 298–306.
   Web of Science ®Google Scholar
• Meng, H.; Mai, W. X.; Zhang, H.; Xue, M.; Xia, T.; Lin, S.; Wang, X.; Zhao, Y.; Ji, Z.; Zink, J. I.; Nel, A. E. Co-delivery of an optimal drug/siRNA combination using mesoporous silica nanoparticle to overcome drug resistance in breast cancer in vitro and in vivo. ACS Nano 2013, 7, 994–1005.
   PubMed Web of Science ®Google Scholar
• Subramanian, N.; Kanwar, J. R.; Athalya, P. K.; Janakiraman, N.; Khetan, V.; Kanwar, R. K.; Eluchuri, S.; Krishnakumar, S. EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex. J. Biomed. Sci. 2015, 22, 4.
   PubMed Web of Science ®Google Scholar
• Shawna, B. C.; George, A. V.; Craig, A. M.; Vamsee, K. C.; Kristen, S.; Robert, L. M.; Alison, C. D.; Brian, S. J. B.; Jeffrey, M. H. Characterization of a novel novobiocin analogue as a putative C terminal inhibitor of heat shock protein 90 in prostate cancer cells. Prostate 2010, 70, 27–36.
   PubMed Web of Science ®Google Scholar
• Floc’h, N.; Kinkade, C. W.; Kobayashi, T.; Aytes, A.; Lefebvre, C.; Mitrofanova, A.; Cardiff, R. D.; Califano, A.; Shen, M. M.; Abate-Shen, C. Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model. Cancer Res. 2012, 72, 4483–4493.
   PubMed Web of Science ®Google Scholar
• Sette, A.; Spadavecchia, J.; Landoulsi, J.; Casale, S.; Haye, B.; Crociani, O.; Arcangeli, A. Development of novel anti-Kv 11.1 antibody-conjugated PEG–TiO2 nanoparticles for targeting pancreatic ductal adenocarcinoma cells. J. Nanopart. Res. 2013, 15, 2111.
   PubMed Web of Science ®Google Scholar
• Maya, S.; Sarmento, B.; Lakshmanan, V.-K.; Menon, D.; Jayakumar, R. Actively targeted cetuximab conjugated γ-poly (glutamic acid)-docetaxel nanomedicines for EGFR over expressing colon cancer cells. J. Biomed. Nanotechnol. 2014, 10, 1416–1428.
   PubMed Web of Science ®Google Scholar
• Maya, S.; Sarmento, B.; Lakshmanan, V.-K.; Menon, D.; Seabra, V.; Jayakumar, R. Chitosan cross-linked docetaxel l loaded EGF receptor targeted nanoparticles for lung cancer cells. Int. J. Biol. Macromol. 2014, 69, 532–541.
   PubMed Web of Science ®Google Scholar
• Naznin-Ara, M.; Hyodo, M.; Ohga, N.; Hida, K.; Harashima, H. Development of a novel DNA aptamer ligand targeting to primary cultured tumor endothelial cells by a cell-based SELEX method. PLoS ONE 2012, 7, e50174.
   PubMed Web of Science ®Google Scholar
• Kang, H. O.; Donoghue, M. B.; Liu, H.; Tan, W. A liposome-based nanostructure for aptamer directed delivery. Chem. Commun (Camb). 2010, 46, 249–251.
   PubMed Web of Science ®Google Scholar
• Liu, Q.; Jin, C.; Wang, Y.; Fang, X.; Zhang, X.; Chen, Z.; Tan, W. Aptamer-conjugated nanomaterials for specific cancer cell recognition and targeted cancer therapy. NPG Asia Mater. 2014, 6, e95.
   PubMed Web of Science ®Google Scholar
• Zhu, J.; Huang, H.; Dong, S.; Ge, L.; Zhang, Y. Progress in aptamer-mediated drug delivery vehicles for cancer targeting and its implications in addressing chemotherapeutic challenges. Theranostics 2014, 4, 931–944.
   PubMed Web of Science ®Google Scholar
• Pack, D. W.; Hoffman, A. S.; Stayton, P. S. P. S. Design and development of polymers for gene delivery. Nat. Rev. Drug Discov. 2005, 4, 581–593.
   PubMed Web of Science ®Google Scholar
• Crystal, R. G. Transfer of genes to humans: Early lessons and obstacles to success. Science 1995, 270, 404–410.
   PubMed Web of Science ®Google Scholar
• Scherer, F.; Anton, M.; Schillinger, U. Magnetofection: Enhancing; and targeting gene delivery by magnetic force in vitro; and in vivo. Gene Ther. 2002, 9, 102–109.
   PubMed Web of Science ®Google Scholar
• Castillo-Rodrıguez, R. A.; Arango-Rodríguez, M. L.; Escobedo, L.; Hernandez-Baltazar, D.; Gompel, A.; Forgez, P.; Martínez-Fong, D. Suicide HSVtk gene delivery by neurotensin polyplex nanoparticles via the bloodstream and GCV treatment specifically inhibit the growth of human MDA-MB-231 triple negative breast cancer tumors xenografted in athymic mice. PLoS ONE 2014, 9, e97151.
   PubMed Web of Science ®Google Scholar
• Hatakeyama, H.; Akita, H.; Kogure, K.; Oishi, M.; Nagasaki, Y.; Kihira, Y.; Ueno, M.; Kobayashi, H.; Kikuchi, H.; Harashima, H. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther. 2007, 14, 68–77.
   PubMed Web of Science ®Google Scholar
• Shao, Z.; Shao, J.; Tan, B.; Guan, S.; Liu, Z.; Zhao, Z.; He, F.; Zhao, J. Targeted lung cancer therapy: Preparation and optimization of transferrin-decorated nanostructured lipid carriers as novel nanomedicine for co-delivery of anticancer drugs and DNA. Int. J. Nanomed. 2015, 10, 1223–1233.
   PubMed Web of Science ®Google Scholar
• DeSano, J. T.; Xu, L. MicroRNA regulation of cancer stem cells and therapeutic implications. AAPS J. 2009, 11, 682–692.
   PubMed Web of Science ®Google Scholar
• Chen, Y.; Zhu, X.; Zhang, X.; Liu, B.; Huang, L. Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Am. Soc. Gene Cell Therapy 2010, 18, 1650–1656.
   PubMed Web of Science ®Google Scholar
• Tivnan, A.; Orr, W. S.; Gubala, V.; Nooney, R.; Williams, D. E.; McDonagh, C.; Prenter, S.; Harvey, H.; Domingo-Fernández, R.; Bray, I. M.; Piskareva, O.; Ng, C. Y.; Lode, H. N.; Davidoff, A. M.; Stallings, R. L. Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PLoS ONE 2012, 7, e38129.
   PubMed Web of Science ®Google Scholar
• Huang, X.; Schwind, S.; Yu, B.; Santhanam, R.; Wang, H.; Hoellerbauer, P.; Mims, A.; Klisovic, R.; Walker, A. R.; Chan, K. K.; Blum, W.; Perrotti, D.; Byrd, J. C.; Bloomfield, C. D.; Caligiuri, M. A.; Lee, R. J.; Garzon, R.; Muthusamy, N.; Lee, L. J.; Marcucci, G. Targeted delivery of microRNA-29b by transferrin conjugated anionic lipopolyplex nanoparticles: A novel therapeutic strategy in acute myeloid leukemia. Clin. Cancer Res. 2013, 19, 2355–2367.
   PubMed Web of Science ®Google Scholar
• Kota, J.; Chivukula, R. R.; O’Donnell, K. A.; Wentzel, E. A.; Montgomery, C. L.; Hwang, H.-W.; Chang, T.-C.; Vivekanandan, P.; Torbenson, M.; Clark, K. R.; Mendell, J. R.; Mendell, J. T. Therapeutic delivery of miR-26a inhibits cancer cell proliferation and induces tumor-specific apoptosis. Cell 2009, 12, 1005–1017.
   Web of Science ®Google Scholar
• Chenna, V.; Hu, C.; Pramanik, D.; Aftab, B. T.; Karikari, C.; Campbell, N. R.; Hong, S.-M.; Zhao, M.; Rudek, M. A.; Khan, S. R.; Rudin, C. M.; Maitra, A. A polymeric nanoparticle encapsulated small-molecule inhibitor of hedgehog signaling of (NanoHHI) bypasses secondary mutational resistance to smoothened antagonists. Mol. Cancer Ther. 2012, 11, 165–173.
   PubMed Web of Science ®Google Scholar
• Thampi, G. R.; Godwin, S. E.; Harish, G. Design and characterization of nanoparticulate drug delivery system of an anticancer drug: Imatinib mesylate. Indian J. Res. Pharm. Biotechnol. 2014, 2, 1082–1087.
   Google Scholar
• Banerjee, S.; Sahoo, A. K.; Chattopadhyay, A.; Ghosh, S. S. Recombinant IκBα-loaded curcumin nanoparticles for improved cancer therapeutics. Nanotechnology 2014, 25, 345102.
   PubMed Web of Science ®Google Scholar
• Kawano, T.; Murata, M.; Piao, J. S.; Narahara, S.; Hamano, N.; Kang, J.-H.; Hashizume, M. Systemic delivery of protein nanocages bearing CTT peptides for enhanced imaging of MMP-2 expression in metastatic tumor models. Int. J. Mol. Sci. 2015, 16, 148–158.
   Web of Science ®Google Scholar
• Won, Y-W.; Yoon, S-M.; Sonn, C. H.; Lee, K-M.; Kim, Y.-H. Nano self-assembly of recombinant human gelatin conjugated with α-tocopheryl succinate for Hsp90 inhibitor, 17-AAG, delivery. ACS Nano 2011, 5, 3839–3848.
   PubMed Web of Science ®Google Scholar
• Qi, W.-W.; Yu, H.-Y.; Guo, H.; Lou, J.; Wang, Z.-M.; Liu, P.; Sapin-Minet, A.; Maincent, P.; Hong, X.-C.; Hu, X.-M.; Xiao, Y.-L. Doxorubicin-loaded glycyrrhetinic acid modified recombinant human serum albumin nanoparticles for targeting liver tumor chemotherapy. Mol. Pharm. 2015, 12, 675–683.
   PubMed Web of Science ®Google Scholar
• Lu, Y.; Zhang, Z.; Yan, Z.; Chen, L.; Deng, W.; Lotze, M.; Wang, Z.; Lin, X.; Li, L. Y. Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo. Apoptosis 2013, 10, 1214–1223.
   Web of Science ®Google Scholar
• Ito, A.; Honda, H.; Kobayashi, T. Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: A novel concept of ‘‘heat-controlled necrosis’’ with heat shock protein expression. Cancer Immunol. Immunother. 2006, 55, 320–328.
   PubMed Web of Science ®Google Scholar
• Chandrasekaran, G.; Hwang, E. C..; Kang, T. W.; Kwon, D. D.; Park, K.; Lee, J. J.; Lakshmanan, V. K. Computational modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer. Sci. Rep. 2017, 7, 43830. doi:10.1038/srep43830.
   PubMed Web of Science ®Google Scholar
• Chandrasekaran, G.; Hwang, E. C.; Kang, T. W.; Kwon, D. D.; Park, K.; Lee, J. J.; Lakshmanan, V. K. In silico analysis of the deleterious nsSNPs (missense) in the homeobox domain of human HOXB13 gene responsible for hereditary prostate cancer. Chem. Biol. Drug Des. 2017.
   PubMed Web of Science ®Google Scholar