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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 68, 2019 - Issue 4
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Original Articles

Curcumin loaded fish scale collagen-HPMC nanogel for wound healing application: Ex-vivo and In-vivo evaluation

Dr Inayat B. PathanDepartment of Pharmaceutics, Government College of Pharmacy, Aurangabad, Maharashtra, IndiaCorrespondence[email protected]
, PhD,
Mr Santosh J. MundeDepartment of Pharmaceutics, Government College of Pharmacy, Aurangabad, Maharashtra, India
,
Dr Santosh ShelkeDepartment of Pharmaceutics, Yash Institute of Pharmacy, Aurangabad, Maharashtra, India
,
Professor Wahid AmbekarDepartment of Pharmaceutics, Dr. VVPF’s College of Pharmacy, Ahmednagar, Maharashtra, India
&
Dr C. Mallikarjuna SettyDepartment of Pharmaceutics, The Oxford College of Pharmacy, Pharmaceutics, Hongasandra, Bangalore, India
Pages 165-174 | Received 27 Oct 2017, Accepted 15 Jan 2018, Published online: 05 Feb 2018
 
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ABSTRACT

The objective of the present investigation was to formulate curcumin loaded fish scale collagen (FSC)-hydroxypropyl methyl cellulose (HPMC K100) nanogel (CNG) for wound healing application. The curcumin nanoemulsion was prepared, characterized and loaded in FSC-HPMC nanogel. The nanogel was evaluated for ex-vivo permeation, in-vivo, skin irritation, and stability study. Ex-vivo permeation study demonstrated that CNG prolonged release and exhibited higher percent contraction value of wound compared to other formulations. In skin irritation study, formulation produced the score of less than 2 compared to control. It concluded that curcumin loaded FSC-HPMC nanogel could be prepared for wound healing applications.

GRAPHICAL ABSTRACT

Acknowledgement

The authors like to acknowledge the All India Council for Technical Education (AICTE), New Delhi for their financial support under CAYT.

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