Development of highly porous, Electrostatic force assisted nanofiber fabrication for biological applications

Abstract

Electrospinning fabricates nano dimensional fibers exhibiting characteristics such as tunable porosity, high surface to volume ratio and the ability to incorporate biocompatible materials in nano fibrous polymeric structures. The ease of fiber functionalization, economic viability and deposition of electro-spun fibers on variety of substrates has made electrospinning sought-after technique in the biomedical field. The applicability of bio-adaptable nanoscale electro-spun fibers is evident in tissue engineering, drug delivery, vascular grafts, implants and neural prostheses, bio-sensing and a plethora of other applications. This review summarizes types and parameters of electrospinning techniques essential for generating highly functional biocompatible nanofibers in future of bio-medicine.

Graphical Abstract

KEYWORDS:

• Biomedical applications
• bioengineering
• drug delivery systems
• electrospinning
• membranes

Acknowledgements

The authors sincerely acknowledge, Dr. C.P. Ramnarayanan, Vice Chancellor of DIAT (DU), Pune, Dr. T. O. Varghese Director, Centre for Biopolymer Science & Technology, Kochi, Kerala, for motivation and support. Authors are also thankful to Mr. Ramdayal Yadav and Mr. Prakash Gore for continuous technical support and help in the revision of this paper.