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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 69, 2020 - Issue 15
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Articles

Polymer-drug conjugates as nanomedicine: a review

Monika Lotansing GiraseDepartment of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India
,
Priyanka Ganeshrao PatilDepartment of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India
&
Pradum Pundlikrao IgeDepartment of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, IndiaCorrespondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0001-8709-5767
ORCID Icon
Pages 990-1014 | Received 28 Mar 2019, Accepted 11 Aug 2019, Published online: 19 Sep 2019
 
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Abstract

The majority of anti-cancer drugs show poor water solubility and produce adverse effects in healthy tissue. The combination of polymer technology and targeted drug delivery system may overlay the way for more effective yet safer therapeutic options for cancer therapy. Polymer drug conjugate are the polymer based prodrugs designed to increase the aqueous solubility of anti-cancers drugs, subsequently enhance the bioavailability. This update introduced basic concept of polymer drug conjugates (PDC) (prodrug) and provided an overview on currently used synthetic strategies for PDCs. In addition, brief overview on various polymer-drug conjugates updating their clinical status and highlights with major anticipated clinical application in cancer therapy.

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