Physicochemical characterization of the gelatin/polycaprolactone nanofibers loaded with diclofenac potassium for topical use aiming potential anti-inflammatory action

Abstract

Common adversities as gastrointestinal discomfort are related to conventional administration of diclofenac potassium (DP), and thus the study of a new administration route based on gelatin/polycaprolactone electrospun nanofibers loaded with DP is an innovative way to create biomaterials for topical delivery of drugs aiming the patients’ life quality improvement. SEM-EDS evidenced success in the drug incorporation, while FTIR and DSC indicated possible gelatin and DP interaction. In vitro biodegradation and in vitro release studies showed the gelatin dissolution and dependence of the release profile with the DP wt. % and temperature, respectively. In vitro permeation presented a dermal targeting of DP.

Graphical Abstract

Keywords:

• Drug delivery systems
• electrospun nanofibers
• nanotechnology
• permeation study
• topical anti-inflammatory biomaterials

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors would like to thank PROEX-CAPES (001 code), CNPq and FAPEMIG for financially supporting the research. The authors also thank Conselho Nacional de Desenvolvimento Científico e Tecnológico;Fundação de Amparo à Pesquisa do Estado de Minas Gerais.