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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 72, 2023 - Issue 2
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Articles

Novel silicone rubber with carboxyl grafted polyhedral oligomeric silsesquioxane (POSS-COOH) as a potential scaffold for soft tissue filling

Xiao-hua Shia Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, The Army Medical University, Chong Qing, China;b Base for Drug Clinical Trial, Xinqiao Hospital, The Army Medical University, Chong Qing, ChinaView further author information
,
Xin Zhoua Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, The Army Medical University, Chong Qing, ChinaView further author information
,
Ze-yuan Leia Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, The Army Medical University, Chong Qing, ChinaView further author information
,
Yuan Tiana Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, The Army Medical University, Chong Qing, ChinaView further author information
,
Yao Chena Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, The Army Medical University, Chong Qing, ChinaView further author information
,
Yi-ming Zhanga Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, The Army Medical University, Chong Qing, ChinaView further author information
,
Tong-chun Maoa Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, The Army Medical University, Chong Qing, ChinaView further author information
,
Dong-li Fana Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, The Army Medical University, Chong Qing, ChinaView further author information
&
Shi-wen Zhoub Base for Drug Clinical Trial, Xinqiao Hospital, The Army Medical University, Chong Qing, ChinaCorrespondence[email protected]
View further author information
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Pages 162-179 | Received 20 Jul 2021, Accepted 26 Oct 2021, Published online: 12 Nov 2021
 
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Abstract

Due to the poor cell compatibility, capsular contracture is usually accompanied by the implantation of Silicone Rubber (SR). In this study, synthetical carboxyl grafted polyhedral oligomeric silsesquioxane (POSS-COOH) was incorporated into SR to prepare a composite filling material, namely POSS-COOH/SR. in vivo implantation showed that the occurrence of capsular formation around POSS-COOH/SR was inhibited, in vitro experiment showed cell improved proliferation and adhesion capability on POSS-COOH/SR. Through proteomics analysis, the extracellular matrix (ECM) regulatory protein in the cells on the surface of POSS-COOH/SR changed significantly. In summary, POSS-COOH/SR could be a better biomaterial to scaffold for soft tissue filling.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Natural Science Foundation of Chongqing, China [No. cstc2020jcyj-msxmX0506].

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