Fabrication of a pH-responsive drug delivery system based on the super-paramagnetic metal-organic framework for targeted delivery of oxaliplatin

Abstract

In this work, the magnetic metal-organic framework was synthesized based on a copper organic framework and Fe₃O₄ magnetic nanoparticles as a novel pH-responsive nanocarrier for oxaliplatin delivery. The magnetic metal-organic framework has been characterized by various analyses, such as Fourier transform infrared spectroscopy, thermogravimetric analysis, CHN analysis, and scanning electron microscopy. The application of the magnetic metal-organic framework as a pH-responsive nanocarrier for oxaliplatin is investigated through in vitro drug release experiments at simulated gastric (pH = 1.2) and simulated intestinal (pH = 7.4) fluids. About 35% of the oxaliplatin was released during 30 min in simulated gastric fluid, while 85% was released in simulated intestinal fluid in 9 h. The metal-organic framework indicated maximum adsorption capacity when the contact time at 10 min, the temperature of 25 °C, the initial concentration of the drug was 20 mg L⁻¹, and pH = 7. Moreover, isotherm studies have shown that oxaliplatin adsorption via this magnetic metal-organic framework was of the Langmuir model.

Graphical Abstract

Keywords:

• Metal-organic framework
• oxaliplatin
• pH-responsive
• super-paramagnetic
• targeted drug delivery