Multifunctional polyethylene glycol-coated Au@MnO nanoparticles for dual-modal CT/MRI and pH-responsive 5-Fluorouracil delivery

Abstract

The combination of imaging contrast media and treatment strategies in one nanosystem has received great attention for cancer detection and treatment. This study aimed to develop Au@MnO/PEG/5FU (AMP/5FU) nanoparticles (NPs) for dual-modal CT/MRI and 5-Fluorouracil (5FU) anticancer drug delivery. The NPs showed a high 5FU loading capacity (90%), pH-responsive release profile, considerable X-ray attenuation, and MRI r1 relaxivity of 4.36 mM⁻¹s⁻¹. They had a significant toxic impact against A549 cancer cells that was greater than that of free 5FU. AMP/5FU NPs can be considered as a high potential multifunctional nanosystem for dual-modal CT/MRI and pH-responsive 5FU delivery.

Graphical Abstract

Keywords:

• Computed tomography
• 5-Fluorouracil
• gold nanoparticles
• loading and release
• magnetic resonance imaging
• manganese oxide

Additional information

Funding

This work was supported by the Medical Radiation Sciences Research Team of Tabriz University of Medical Sciences under Grant number 64524. This research was extracted from the MSc thesis under ethical code 1398.404.