A comprehensive review on carrier mediated nose to brain targeting: emphasis on molecular targets, current trends, future prospects, and challenges

Abstract

Several therapeutic agents are used for controlling brain diseases, but they are not successfully reaching target sites due to the complex nature of the brain. Nasal administration as an alternate administration route has been proposed for brain targeting. To solve the above limitation linked to brain targeting through the transmission of nasal products, encourage the production of novel drug delivery by the combination of nanotechnology. The present review focuses on the latest understanding of pathways underlying central nervous system intranasal transmission. Novel Drug delivery systems as important methods for targeting the brain without toxicity in the nasal mucosa and central nervous system, they have acquired the capacity of CNS.

Graphical Abstract

Keywords:

• Brain targeting
• CNS disorder
• delivery system
• nanoparticles
• nose

Acknowledgments

The authors are thankful to the Institute of Pharmaceutical Research (IPR), GLA University, Mathura for providing the necessary facilities.

Disclosure statement

No potential conflict of interest was reported by the author(s).