Multi-stimuli-responsive starch/MnO₂ microparticles hydrogel for synergistic chemoradiotherapy of breast cancer

Abstract

Microparticles hydrogel sensitive to reduction, pH and radiation composed of starch (St) and MnO₂ NPs were synthesized, and loaded with Dox for in vitro treatment of MCF-7 cells. LE and EE values were obtained as 3.12 and 93.4%, respectively. In vitro drug release study revealed pH- and reduction-responsiveness drug release behavior of the DDS. The intracellular uptake of the St/MnO₂ microparticles was verified through FITC dye conjugation. The St-MnO₂/Dox microparticles exhibited higher anticancer activity than free Dox after 48 h as verified by MTT and DAPI staining assays. As results, combined chemoradiotherapy approach exhibited synergistic outcomes than chemotherapy alone.

Graphical Abstract

A pH-, redox-, and radiation-sensitive microparticles hydrogel as drug delivery system (DDS) was designed and developed based on starch and MnO₂ nanoparticles for synergistic in vitro chemoradiotherapy of MCF-7 cells.

Keywords:

• Breast cancer
• chemoradiotherapy
• microparticle hydrogel
• MnO₂ nanoparticles
• starch

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

All data generated or analyzed during this study are included in this published article.

Additional information

Funding

The work was supported by Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran, and the Research Council of Kermanshah University of Medical Sciences, Kermanshah, Iran (Grant Number: 4010351).