Multi-stimuli-responsive starch/MnO₂ microparticles hydrogel for synergistic chemoradiotherapy of breast cancer

References

• Sung, H.; Ferlay, J.; Siegel, R. L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA. Cancer J. Clin. 2021, 71, 209–249. DOI: 10.3322/caac.21660.
   PubMed Web of Science ®Google Scholar
• Karim, S.; Akhter, M. H.; Burzangi, A. S.; Alkreathy, H.; Alharthy, B.; Kotta, S.; Md, S.; Rashid, M. A.; Afzal, O.; Altamimi, A. S. A.; Khalilullah, H. Phytosterol-Loaded Surface-Tailored Bioactive-Polymer Nanoparticles for Cancer Treatment: Optimization, In Vitro Cell Viability, Antioxidant Activity, and Stability Studies. Gels. 2022, 8, 219. DOI: 10.3390/gels8040219.
   PubMed Web of Science ®Google Scholar
• Roth, G. A.; Mensah, G. A.; Johnson, C. O.; Addolorato, G.; Ammirati, E.; Baddour, L. M.; Barengo, N. C.; Beaton, A. Z.; Benjamin, E. J.; Benziger, C. P; et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update from the GBD 2019 Study. J. Am. Coll. Cardiol. 2020, 76, 2982–3021. DOI: 10.1016/j.jacc.2020.11.010.
   PubMed Web of Science ®Google Scholar
• Schirrmacher, V. From Chemotherapy to Biological Therapy: A Review of Novel Concepts to Reduce the Side Effects of Systemic Cancer Treatment (Review). Int. J. Oncol. 2019, 54, 407–419. DOI: 10.3892/ijo.2018.4661.
   PubMed Web of Science ®Google Scholar
• Habban Akhter, M.; Amin, S. An Investigative Approach to Treatment Modalities for Squamous Cell Carcinoma of Skin. Curr. Drug Deliv. 2017, 14, 597–612. DOI: 10.2174/1567201801666160906104254.
   PubMed Web of Science ®Google Scholar
• Massoumi, B.; Abbasian, M.; Jahanban‐Esfahlan, R.; Motamedi, S.; Samadian, H.; Rezaei, A.; Derakhshankhah, H.; Farnudiyan‐Habibi, A.; Jaymand, M. PEGylated Hollow pH‐Responsive Polymeric Nanocapsules for Controlled Drug Delivery. Polym. Int. 2020, 69, 519–527. DOI: 10.1002/pi.5987.
   Web of Science ®Google Scholar
• Ferlay, J.; Colombet, M.; Soerjomataram, I.; Parkin, D. M.; Piñeros, M.; Znaor, A.; Bray, F. Cancer Statistics for the Year 2020: An Overview. Int. J. Cancer. 2021, 149, 778–789. DOI: 10.1002/ijc.33588.
   Web of Science ®Google Scholar
• Yedjou, C. G.; Sims, J. N.; Miele, L.; Noubissi, F.; Lowe, L.; Fonseca, D. D.; Alo, R. A.; Payton, M.; Tchounwou, P. B. Breast Cancer Metastasis and Drug Resistance. َAdv. Exp. Med. Biol. 2019, 11252, 31–49.
   Google Scholar
• Britt, K. L.; Cuzick, J.; Phillips, K.-A. Key Steps for Effective Breast Cancer Prevention. Nat. Rev. Cancer. 2020, 20, 417–436. DOI: 10.1038/s41568-020-0266-x.
   PubMed Web of Science ®Google Scholar
• Afzal, O.; Akhter, M. H.; Ahmad, I.; Muzammil, K.; Dawria, A.; Zeyaullah, M.; Altamimi, A. S. A.; Khalilullah, H.; Mir Najib Ullah, S. N.; Rahman, M. A.; et al. A β–Sitosterol Encapsulated Biocompatible Alginate/Chitosan Polymer Nanocomposite for the Treatment of Breast Cancer. Pharmaceutics. 2022, 14, 1711. DOI: 10.3390/pharmaceutics14081711.
   PubMed Web of Science ®Google Scholar
• Salas-Benito, D.; Pérez-Gracia, J. L.; Ponz-Sarvisé, M.; Rodriguez-Ruiz, M. E.; Martínez-Forero, I.; Castañón, E.; López-Picazo, J. M.; Sanmamed, M. F.; Melero, I. Paradigms on Immunotherapy Combinations with Chemotherapy. Cancer Discov. 2021, 11, 1353–1367. DOI: 10.1158/2159-8290.CD-20-1312.
   PubMed Web of Science ®Google Scholar
• Pucci, C.; Martinelli, C.; Ciofani, G. Innovative Approaches for Cancer Treatment: current Perspectives and New Challenges. Ecancer. 2019, 13, 961. DOI: 10.3332/ecancer.2019.961.
   PubMed Web of Science ®Google Scholar
• Khani, A.; Eskandani, M.; Derakhshankhah, H.; Soleimani, K.; Nakhjavani, S. A.; Massoumi, B.; Jahanban-Esfahlan, R.; Moloudi, K.; Jaymand, M. A Novel Stimuli-Responsive Magnetic Hydrogel Based on Nature-Inspired Tragacanth Gum for Chemo/Hyperthermia Treatment of Cancerous Cells. J. Polym. Res. 2022, 29, 149. DOI: 10.1007/s10965-022-03004-7.
   Web of Science ®Google Scholar
• Samadian, H.; Mohammad-Rezaei, R.; Jahanban-Esfahlan, R.; Massoumi, B.; Abbasian, M.; Jafarizad, A.; Jaymand, M. A De Novo Theranostic Nanomedicine Composed of PEGylated Graphene Oxide and Gold Nanoparticles for Cancer Therapy. J. Mater. Res. 2020, 35, 430–441. DOI: 10.1557/jmr.2020.3.
   Web of Science ®Google Scholar
• Nedeljković, M.; Damjanović, A. Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge. Cells. 2019, 8, 957. DOI: 10.3390/cells8090957.
   PubMed Web of Science ®Google Scholar
• Bukowski, K.; Kciuk, M.; Kontek, R. Mechanisms of Multidrug Resistance in Cancer Chemotherapy. Int. J. Mol. Sci. 2020, 21, 3233. DOI: 10.3390/ijms21093233.
   PubMed Web of Science ®Google Scholar
• Zhang, Q.-Y.; Wang, F.-X.; Jia, K.-K.; Kong, L.-D. Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects. Front. Pharmacol. 2018, 9, 1253. DOI: 10.3389/fphar.2018.01253.
   PubMed Web of Science ®Google Scholar
• Liu, Y.-Q.; Wang, X.-L.; He, D.-H.; Cheng, Y.-X. Protection against Chemotherapy- and Radiotherapy-Induced Side Effects: A Review Based on the Mechanisms and Therapeutic Opportunities of Phytochemicals. Phytomedicine. 2021, 80, 153402. DOI: 10.1016/j.phymed.2020.153402.
   PubMed Web of Science ®Google Scholar
• Watanabe, T.; Yagata, H.; Saito, M.; Okada, H.; Yajima, T.; Tamai, N.; Yoshida, Y.; Takayama, T.; Imai, H.; Nozawa, K.; et al. A Multicenter Survey of Temporal Changes in Chemotherapy-Induced Hair Loss in Breast Cancer Patients. PLoS One. 2019, 14, e0208118. DOI: 10.1371/journal.pone.0208118.
   PubMed Web of Science ®Google Scholar
• Su, M.-H.; Chen, G.-Y.; Lin, J.-H.; Lee, H. H.; Chung, K.-C.; Wang, P.-H. Paclitaxel-Related Dermatological Problems: Not Only Alopecia Occurs. Taiwan. J. Obstet. Gynecol. 2019, 58, 877–879. DOI: 10.1016/j.tjog.2019.08.003.
   PubMed Web of Science ®Google Scholar
• Arjmand, F.; Salami-Kalajahi, M.; Roghani-Mamaqani, H. Preparation of Photolabile Nanoparticles by Coumarin-Based Crosslinker for Drug Delivery under Light Irradiation. J. Phys. Chem. Solids. 2021, 154, 110102. DOI: 10.1016/j.jpcs.2021.110102.
   Web of Science ®Google Scholar
• Sahiner, B.; Pezeshk, A.; Hadjiiski, L. M.; Wang, X.; Drukker, K.; Cha, K. H.; Summers, R. M.; Giger, M. L. Deep Learning in Medical Imaging and Radiation Therapy. Med. Phys. 2019, 46, e1–e36. DOI: 10.1002/mp.13264.
   PubMed Web of Science ®Google Scholar
• Nickoloff, J. A.; Sharma, N.; Taylor, L. Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy. Genes. 2020, 11, 99. DOI: 10.3390/genes11010099.
   PubMed Web of Science ®Google Scholar
• Chen, H. H.; Kuo, M. T. Improving Radiotherapy in Cancer Treatment: Promises and Challenges. Oncotarget. 2017, 8, 62742–62758. DOI: 10.18632/oncotarget.18409.
   PubMedGoogle Scholar
• Zhang, Q.; Liu, J.; Ao, N.; Yu, H.; Peng, Y.; Ou, L.; Zhang, S. Secondary Cancer Risk after Radiation Therapy for Breast Cancer with Different Radiotherapy Techniques. Sci. Rep. 2020, 10, 1220. DOI: 10.1038/s41598-020-58134-z.
   Web of Science ®Google Scholar
• Majeed, H.; Gupta, V. Adverse Effects of Radiation Therapy; StatPearls Publishing: Treasure Island (FL), 2021.
   Google Scholar
• Rallis, K. S.; Yau, T. H. L.; Sideris, M. Chemoradiotherapy in Cancer Treatment: Rationale and Clinical Applications. Anticancer Res. 2021, 41, 1–7. DOI: 10.21873/anticanres.14746.
   PubMed Web of Science ®Google Scholar
• You, R.; Liu, Y.-P.; Huang, P.-Y.; Zou, X.; Sun, R.; He, Y.-X.; Wu, Y.-S.; Shen, G.-P.; Zhang, H.-D.; Duan, C.-Y.; et al. Efficacy and Safety of Locoregional Radiotherapy with Chemotherapy vs Chemotherapy Alone in De Novo Metastatic Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial. JAMA Oncol. 2020, 6, 1345–1352. DOI: 10.1001/jamaoncol.2020.1808.
   PubMed Web of Science ®Google Scholar
• Edeline, J.; Touchefeu, Y.; Guiu, B.; Farge, O.; Tougeron, D.; Baumgaertner, I.; Ayav, A.; Campillo-Gimenez, B.; Beuzit, L.; Pracht, M.; et al. Radioembolization plus Chemotherapy for First-Line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial. JAMA Oncol. 2020, 6, 51–59. DOI: 10.1001/jamaoncol.2019.3702.
   PubMed Web of Science ®Google Scholar
• Mi, Y.; Shao, Z.; Vang, J.; Kaidar-Person, O.; Wang, A. Z. Application of Nanotechnology to Cancer Radiotherapy. Cancer Nano. 2016, 7, 1–16. DOI: 10.1186/s12645-016-0024-7.
   PubMedGoogle Scholar
• Ahmad, J.; Ahmad, M. Z.; Akhter H.; Ameeduzzafar. Surface-Engineered Cancer Nanomedicine: Rational Design and Recent Progress. Curr. Pharm. Des. 2020, 26, 1181–1190. DOI: 10.2174/1381612826666200214110645.
   PubMed Web of Science ®Google Scholar
• Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an emerging platform for cancer therapy. Nano-Enabled Medical Applications. Taylor & Francis Group: Boca Raton, FL, 2020, 61-91.
   Google Scholar
• Jin, C.; Wang, K.; Oppong-Gyebi, A.; Hu, J. Application of Nanotechnology in Cancer Diagnosis and Therapy - A Mini-Review. Int. J. Med. Sci. 2020, 17, 2964–2973. DOI: 10.7150/ijms.49801.
   PubMed Web of Science ®Google Scholar
• Song, G.; Cheng, L.; Chao, Y.; Yang, K.; Liu, Z. Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy. Adv. Mater. 2017, 29, 1700996. DOI: 10.1002/adma.201700996.
   Web of Science ®Google Scholar
• Cai, X.; Zhu, Q.; Zeng, Y.; Zeng, Q.; Chen, X.; Zhan, Y. Manganese Oxide Nanoparticles as MRI Contrast Agents in Tumor Multimodal Imaging and Therapy. Int. J. Nanomed. 2019, 14, 8321–8344. DOI: 10.2147/IJN.S218085.
   PubMed Web of Science ®Google Scholar
• Chang, C.-C.; Dinh, T. K.; Lee, Y.-A.; Wang, F.-N.; Sung, Y.-C.; Yu, P.-L.; Chiu, S.-C.; Shih, Y.-C.; Wu, C.-Y.; Huang, Y.-D.; et al. Nanoparticle Delivery of MnO2 and Antiangiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma. ACS Appl. Mater. Interfaces. 2020, 12, 44407–44419. DOI: 10.1021/acsami.0c08473.
   PubMed Web of Science ®Google Scholar
• Yang, G.; Ji, J.; Liu, Z. Multifunctional MnO(2) nanoparticles for tumor microenvironment modulation and cancer therapy. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2021, 13, e1720.
   PubMed Web of Science ®Google Scholar
• Sood, N.; Bhardwaj, A.; Mehta, S.; Mehta, A. Stimuli-Responsive Hydrogels in Drug Delivery and Tissue Engineering. Drug Delivery. 2016, 23, 748–770. DOI: 10.3109/10717544.2014.940091.
   Web of Science ®Google Scholar
• Ferreira, N.; Ferreira, L.; Cardoso, V.; Boni, F.; Souza, A.; Gremião, M. Recent Advances in Smart Hydrogels for Biomedical Applications: From Self-Assembly to Functional Approaches. Eur. Polym. J. 2018, 99, 117–133. DOI: 10.1016/j.eurpolymj.2017.12.004.
   Web of Science ®Google Scholar
• Peppas, N. A.; Mikos, A. G.. Preparation Methods and Structure of Hydrogels; In Hydrogels in Medicine and Pharmacy. CRC Press: Boca Raton, 2019; pp. 1–26.
   Google Scholar
• Motamedi, S.; Massoumi, B.; Jaymand, M.; Derakhshankhah, H.; Alizadeh, E. Bioreducible and pH-Responsive Shell Crosslinked Polymeric Micelles from a Star-Shaped Terpolymer as Drug Delivery System. Int. J Polym. Mater. Polym. Biomater. 2022, 71, 481–492. DOI: 10.1080/00914037.2020.1857382.
   Web of Science ®Google Scholar
• Safavi-Mirmahalleh, S.-A.; Salami-Kalajahi, M.; Roghani-Mamaqani, H. Adsorption Kinetics of Methyl Orange from Water by pH-Sensitive Poly(2-(Dimethylamino)Ethyl Methacrylate)/Nanocrystalline Cellulose Hydrogels. Environ. Sci. Pollut. Res. Int. 2020, 27, 28091–28103. DOI: 10.1007/s11356-020-09127-y.
   PubMed Web of Science ®Google Scholar
• Li, J.; Mooney, D. J. Designing Hydrogels for Controlled Drug Delivery. Nat. Rev. Mater. 2016, 1, 1–17. DOI: 10.1038/natrevmats.2016.71.
   Web of Science ®Google Scholar
• Narayanaswamy, R.; Torchilin, V. P. Hydrogels and Their Applications in Targeted Drug Delivery. Molecules. 2019, 24, 603. DOI: 10.3390/molecules24030603.
   PubMed Web of Science ®Google Scholar
• Derakhshankhah, H.; Haghshenas, B.; Eskandani, M.; Jahanban-Esfahlan, R.; Abbasi-Maleki, S.; Jaymand, M. Folate-Conjugated Thermal- and pH-Responsive Magnetic Hydrogel as a Drug Delivery Nano-System for “Smart” Chemo/Hyperthermia Therapy of Solid Tumors. Mater. Today Commun. 2022, 30, 103148. DOI: 10.1016/j.mtcomm.2022.103148.
   Web of Science ®Google Scholar
• Masina, N.; Choonara, Y. E.; Kumar, P.; Du Toit, L. C.; Govender, M.; Indermun, S.; Pillay, V. A Review of the Chemical Modification Techniques of Starch. Carbohydr. Polym. 2017, 157, 1226–1236. DOI: 10.1016/j.carbpol.2016.09.094.
   PubMed Web of Science ®Google Scholar
• Jiang, T.; Duan, Q.; Zhu, J.; Liu, H.; Yu, L. Starch-Based Biodegradable Materials: Challenges and Opportunities. Adv. Ind. Eng. Polym. Res. 2020, 3, 8–18. DOI: 10.1016/j.aiepr.2019.11.003.
   Google Scholar
• Quintanilla de Stéfano, J. C.; Abundis-Correa, V.; Herrera-Flores, S. D.; Alvarez, A. J. pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior. Polymers. 2020, 12, 1974. DOI: 10.3390/polym12091974.
   PubMed Web of Science ®Google Scholar
• Chyzy, A.; Tomczykowa, M.; Plonska-Brzezinska, M. E. Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery. Materials. 2020, 13, 188. DOI: 10.3390/ma13010188.
   PubMed Web of Science ®Google Scholar
• Akhter, M. H.; Beg, S.; Tarique, M.; Malik, A.; Afaq, S.; Choudhry, H.; Hosawi, S. Receptor-Based Targeting of Engineered Nanocarrier against Solid Tumors: Recent Progress and Challenges Ahead. Biochim. Biophys. Acta. Gen. Subj. 2021, 1865, 129777. DOI: 10.1016/j.bbagen.2020.129777.
   PubMed Web of Science ®Google Scholar
• Nikravan, G.; Haddadi-Asl, V.; Salami-Kalajahi, M. Stimuli-Responsive DOX Release Behavior of Cross-Linked Poly(Acrylic Acid) Nanoparticles. e-Polymers. 2019, 19, 203–214. DOI: 10.1515/epoly-2019-0021.
   Web of Science ®Google Scholar
• Kennedy, L.; Sandhu, J. K.; Harper, M.-E.; Cuperlovic-Culf, M. Role of Glutathione in Cancer: From Mechanisms to Therapies. Biomolecules 2020, 10, 1429. DOI: 10.3390/biom10101429.
   PubMed Web of Science ®Google Scholar
• Bansal, A.; Simon, M. C. Glutathione Metabolism in Cancer Progression and Treatment Resistance. J. Cell Biol. 2018, 217, 2291–2298. DOI: 10.1083/jcb.201804161.
   PubMed Web of Science ®Google Scholar
• Kahattha, C.; Santhaveesuk, S. Influence of Calcination Temperature on Physical and Electrochemical Properties of MnO 2 Nanoparticles Synthesized by Co-Precipitation Method. Ferroelectrics. 2019, 552, 121–131. DOI: 10.1080/00150193.2019.1653088.
   Web of Science ®Google Scholar
• Baral, A.; Satish, L.; Zhang, G.; Ju, S.; Ghosh, M. K. A Review of Recent Progress on Nano MnO2: Synthesis, Surface Modification and Applications. J. Inorg. Organomet. Polym. 2021, 31, 899–922. DOI: 10.1007/s10904-020-01823-z.
   Web of Science ®Google Scholar
• Manjula, R.; Thenmozhi, M.; Thilagavathi, S.; Srinivasan, R.; Kathirvel, A. Green Synthesis and Characterization of Manganese Oxide Nanoparticles from Gardenia resinifera Leaves. Mater. Today: Proc. 2020, 26, 3559–3563. DOI: 10.1016/j.matpr.2019.07.396.
   Google Scholar
• Poorgholy, N.; Massoumi, B.; Jaymand, M. A Novel Starch-Based Stimuli-Responsive Nanosystem for Theranostic Applications. Int. J. Biol. Macromol. 2017, 97, 654–661. DOI: 10.1016/j.ijbiomac.2017.01.063.
   PubMed Web of Science ®Google Scholar
• Yuan, A.; Wang, X.; Wang, Y.; Hu, J. Textural and Capacitive Characteristics of MnO2 Nanocrystals Derived from a Novel Solid-Reaction Route. Electrochim. Acta. 2009, 54, 1021–1026. DOI: 10.1016/j.electacta.2008.08.057.
   Web of Science ®Google Scholar