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Publication Cover
The American Journal of Drug and Alcohol Abuse
Encompassing All Addictive Disorders
Volume 32, 2006 - Issue 4
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Original

Modafinil and Cocaine Interactions

Robert Malcolm Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, South Carolina, USACorrespondence[email protected]
,
Karla Swayngim Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, South Carolina, USA
,
Jennifer L. Donovan Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, South Carolina, USA
,
C. Lindsay DeVane Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, South Carolina, USA
,
Ahmed Elkashef National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA
,
Nora Chiang National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA
,
Roberta Khan Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, South Carolina, USA
,
Jurij Mojsiak National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA
,
Donald L. Myrick Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, South Carolina, USA
,
Sarra Hedden Department of Biostatistics, Bioinformatics and Epidemiology, MUSC, Charleston, South Carolina, USA
,
Kristi Cochran Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, South Carolina, USA
&
Robert F. Woolson Department of Biostatistics, Bioinformatics and Epidemiology, MUSC, Charleston, South Carolina, USA
 show all
Pages 577-587 | Published online: 07 Jul 2009
 
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Abstract

This Phase I trial evaluated the interaction between modafinil steady-state and cocaine. Twelve non-treatment seeking, cocaine dependent volunteers received four sets of randomized blinded infusions of saline, 20 mg IV cocaine, and 40 mg IV cocaine. Modafinil was given open label at 0 mg, 400 mg, or 800 mg. Modafinil combined with IV cocaine did not result in any significant hemodynamic interactions. Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted.

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