Salting-out assisted liquid-liquid extraction method combined with GC-MS for the determination of topiramate in aqueous solutions: development and application of the methodology

ABSTRACT

The drugs are emerging pollutants with great evidence in several scientific studies directed to the removal and separation of these contaminants from aquatic environments. The present study provides an efficient methodology for the determination of the topiramate in aqueous solutions by salting-out assisted liquid-liquid extraction-gas chromatography coupled to mass spectrometry, obtaining optimum recovery efficiency of topiramate, 99.0%. The methodology validation showed linearity with detection limits of 10.23 mg/L and quantification of 30.99 mg/L. The application of the method was founded in monitoring of adsorption assay of drug in perlita expandida, that has been demonstrated efficient (34.0% adsorption removal), since topiramate is a potential micropollutants of aqueous environment.

KEYWORDS:

• Topiramate
• antiepileptic drug
• water sample
• Salting-out assisted liquid–liquid extraction
• GC-MS

Acknowledgments

Thanks to the Comissão de Apoio Pessoal do Ensino Superior (CAPES) for financial support, to FINEP, CNPQ and PETROBRAS for the instrumental support, to Analytical Center of the Institute of Chemistry (UFRN) for GC-MS analyses. Núcleo de Pesquisa em Alimentos e Medicamentos (NUPLAM) for the active principle of topiramate, to Professor Dr. Carlos Alberto Martinez Huitler (IQ-UFRN) for the contribution with inputs, and to Elmar D. Júnior (IQ-UFRN) for the figures.

Additional information

Funding

This work was supported by Comissão de Apoio Pessoal do Ensino Superior (CAPES).