ABSTRACT
Objectives: High sodium intake is associated with a higher risk of stroke. However, global patterns and trends in the stroke burden attributable to high sodium intake have not been systematically assessed.
Methods: We used the numbers and age-standardized mortality rate (ASMR), and disability-adjusted life years (DALYs) rate (ASDR) of the stroke burden attributable to high sodium intake by sex, socio-demographic index (SDI), and country, obtained from the Global Burden of Disease Study (GBD) 2019. We calculated the estimated annual percentage changes (EAPCs) to assess the trends of ASMR and ASDR of the disease burden attributable to high sodium intake between 1990 and 2019. We further calculated the contribution of changes in population growth, population aging, and mortality or DALYs to changes in total stroke deaths and DALYs.
Results: From 1990 to 2019, the global burden of stroke attributable to high sodium intake changed significantly, from a universal burden in Asia and Europe to one that mainly affected some countries in Asia and Oceania. This change was due to the combined effects of demographic changes and changes in mortality or DALY rates. For countries in Asia and Oceania, the effects of population aging and population growth outweighed the effects of declining mortality and DALY rates, resulting in an absolute increase in strokes attributable to high sodium intake.
Conclusion: Although the age-standardized global stroke burden attributable to high sodium intake has declined from 1990 to 2019, the burdens in some Asia and Oceania countries, particularly China, remain high.
Acknowledgments
We thank all individuals who have contributed to the Global Burden of Disease 2017 study.
Disclosure of interests
The authors report no conflicts of interest.
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Notes on contributors
Lina Wang
Dr. Lina Wang is a neurologist in the Ninth Hospital of Xi'an affiliated to the Medical School of Xi'an Jiaotong University. Her research focuses on the diagnosis and treatment of stroke, as well as the epidemiology of stroke.
Jianqiang Du
Dr. Jianqiang Du is a lecturer in the School of Life Science and Technology of Xi'an Jiaotong University. His research focuses on bioinformatics and medical epidemiology.Dr. Wangnan Cao is a research associate at the Brown University School of Public Health. Her research interests are behavioral health and health promotion.
Wangnan Cao
Dr. Wangnan Cao is a research associate at the Brown University School of Public Health. Her research interests are behavioral health and health promotion.
Shengzhi Sun
Dr. Shengzhi Sun is a research scientist at the Boston University School of Public Health. His research focuses on estimating the impact of air pollution and climate change on human health.